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《JOURNAL OF BEIJING MEDICAL UNIVERSITY》 1996-04
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EFFECTS OF TREMELLA POLYSACCHARIDES ON IL-2,IL-6,TNF-α ACTIVITY AND THEIR mRNA EXPRESSIONS IN MICE

CUI Jinying;LIN Zhibin(Departrnent of Pharrmacology,Beijng Medical University l 00083)  
Objective:Effect of Tremella polysaccharides(TP),a polysarccharides isolated from Tremel- la fuciformis Berk.on IL-2,11-6 and TNF-a activity and their mRNA expressions was observed in mice,Methods:Activity of IL-2 IL-6 and TNF-a was detected in murine splenocytes by bioassay using CTLL,7TDl and WEHI-164 cell line respectively,mRNA expression of IL-2,IL-6 and TNF-a was per- formed by northern blot hybridization in mice。 Results:TP(100 mg/L)increased the activity of IL-2in the supernatant of murine splenocytes with or without ConA(2.5 mg/L).The effects reached maximum after 24 hours incubation and afterwards abated.TP(25,100 mg/L)enhanced the activity of IL-6 in the supernatant of murine peritoneal macrophage with LPS(10 mg/L。)and achieved the maximum at the end of 48 hours’incubation after treatment.TP(25,100 mg/L。)with LPS(10 my/L)markedly in- creased the activity of TNF-a,but TP alone without LtPS had no obvious effect.TP can promote IL-2,IL-6 and TNF-a mRNA expessions in a dose-dependent manner with the maximal effecfive dose of 200 mgl/g,ig.The time-course study showed that these mRNA expression occurred maximum in 9 daysafter treatment with TP,Conclusion:TP increased the production of IL-2,IL-6 and TNF-a by promoting the mRNA expression of these cvtokins.
【CateGory Index】: R285.5
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