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《Journal of Beijing Medical University》 1996-06
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GF Shujun;TANG Chaoshu ;PANG Yongzheng ;CHENG Shi(Department of Biophysics,Beijing Medical University100083)  
Objective:To study the protective effect of metallothionein on rat liver mitochondria dam-aged by oxygen free radical and its mechanism.Methods:On the model of mitochondria damaged by Fe-SO4/ascorbic acid free radical generating system,Ca(2+)/Mg(2+) ATPase activity and Ca(2+) uptake were ob-served and assayed.Results;Metallothionein attenuated decrease of Ca(2+)/Mg(2+) ATPase activity and Ca(2+) uptake induced hy oxygen free radical (P0.01)in dose-dependent manner.Conclusion;Metal-lothionein could protect mitochondria from oxygen free radical.Mitochondria protection of metalloth-ionein may be involved in the mechanisrn of cell protection of this protein.
【CateGory Index】: R977.6
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