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《Journal of Beijing Medical University》 1996-06
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PROTECTIVE EFFECT OF METALLOTHIONEIN ON RAT LIVER MITOCHONDRIA DAMAGED BY OXYGEN FREE RADICAL

GF Shujun;TANG Chaoshu ;PANG Yongzheng ;CHENG Shi(Department of Biophysics,Beijing Medical University100083)  
Objective:To study the protective effect of metallothionein on rat liver mitochondria dam-aged by oxygen free radical and its mechanism.Methods:On the model of mitochondria damaged by Fe-SO4/ascorbic acid free radical generating system,Ca(2+)/Mg(2+) ATPase activity and Ca(2+) uptake were ob-served and assayed.Results;Metallothionein attenuated decrease of Ca(2+)/Mg(2+) ATPase activity and Ca(2+) uptake induced hy oxygen free radical (P0.01)in dose-dependent manner.Conclusion;Metal-lothionein could protect mitochondria from oxygen free radical.Mitochondria protection of metalloth-ionein may be involved in the mechanisrn of cell protection of this protein.
【CateGory Index】: R977.6
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【References】
Chinese Journal Full-text Database 6 Hits
1 SONG Chen1,ZHANG Jun2 (1.Physical department of HeFei university of Technology,HeFei 230009,AnHui China;2.College of Physical Education of YangZhou university,YangZhou 225002,JiangSu China);The Protective effects of Exhaustive exercise Metallothionein in Induced by Zinc on Myocardium in Heart of Rats[J];北京体育大学学报;2008-02
2 ZHANG Xiao-wen,SONG Qing,XU Zhi-wei(Department of basic theory of Traditional Chinese Medicine,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,Guangdong China);Significance of Metallothioneins on study of Liver Bears the Depressive Effect[J];辽宁中医杂志;2006-02
3 ;Metallothionein and Ischemia-reperfusion injury[J];中国美容医学;2005-02
4 LI Hong, WANG Ke-yue, SHI Xiu-quan(Department of Preventive Medicine, Zunyi Medical College, Guizhou Zunyi 563003, China);Study on the protective effects of pre-supplement zinc on liver lipid peroxidation damage of rat induced by cadmium[J];遵义医学院学报;2004-04
5 YANG Jing-Hui, CHANG lin, TANG Chao-Shu △ (Department of Physiology and Pathophysiology,Peking University School of Basic Medical Sciences, Beijing 100083,China);Metallothionein- cardiovascular cytoprotective agent[J];北京大学学报(医学版);2002-05
6 PENG Hong;CHENG Ming-liang Department of lnfectious Diseases,Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China;The relationship of metallothionein and liver fibrosis[J];中华肝脏病杂志;2008-01
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 CHEN Wei-qiang, CHENG Yi-yong, LI Shu-tian, WANG Dong-lan, HONG Yan (Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050);EFFECTS OF RESTRAINT STRESS ON THE EXPR ESSION OF METALLOTHIONEINS IN HIPPOCAMPUS OF RAT[J];营养学报;2003-04
2 KE Qin-Mei, FENG Yi-Bai 1, CHENG Bei,GUAN Si-Ming, LI Wei, CHEN Xue-Lin (Dept of Geriatrics, 1Institute of Cardiology, the Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022);Protective effects of metallothionein induced by Zn~(2+) on ischemia/reperfusion myocardium in isolated rat heart[J];中国药理学通报;2003-11
3 GUO Jie *, WANG Dong-yan, GUAN De-hong, TANG Chao-shu. *Department of Plastic Surgery, the Second Hospital, Harbin University, Harbin 150086, China;;The effect of liposome-carried metallothionein on secondary venous ischemia-reperfusion injury in a rat flap[J];中华整形外科杂志;2003-04
4 GAO Lin 1, WANG Dongyan 1, LI Yang 2, SHI Yanrong 1, BU Dingfang 1, PANG Yongzheng 1, TANG Chaoshu 1△ (1. Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China; 2.Department of Clinical Medicine, Peking University Health Science Center);The synthesis of MT in rat myocardial fibroblasts[J];北京大学学报(医学版);2003-01
5 YANG Jing-Hui, CHANG lin, TANG Chao-Shu △ (Department of Physiology and Pathophysiology,Peking University School of Basic Medical Sciences, Beijing 100083,China);Metallothionein- cardiovascular cytoprotective agent[J];北京大学学报(医学版);2002-05
6 GUO Jie,JIANG Hong chi,WANG Shu jie,et al Department of Plastic surgery,the Second Hospital of Haerbin Medical University,(HaOerbin 150086);METALLOTHION CAN REINFORTH THE DELAYED PROTECTION THROUGH PRECONDITION OF FLAP ISCHEMIA[J];中国美容医学;2002-01
7 JING Yu-gang, GUO Chang-jing, YANG Ji-jun, HONG Yan, GAO Lan-xing (Institute of Hygiene and Environmental Medicine, AMMS Tianjin 300050, China);The Comparative Study on the Protective Effect of Zinc and Metallothionein Against Hepatic Ischemia-reperfusion Injury[J];营养学报;2001-04
8 LI Shu-lian, WANG Xiao-hong, FU Min-gui, PANG Yong-zheng, TANG Chao-shu (Institute of Cardiovascular Research, The First Hospital, Peking University, Beijing 100034, China);Metallothionein involvement in myocardial protection of basic fibroblast growth factor[J];中国病理生理杂志;2000-12
9 QI Yong Fen, LI Shu Lian, WANG Xiao Hong, Chen Ya Hong, PANG Yong Zheng, CHEN Qing, TANG Chao Shu (Institute of Cardiovascular Research,the First Hospital,Beijing Medical University,Beijng 100034);Antagonistic effect of metallothionein against homocysteine induced vascular endothelial cell injury[J];中国药理学通报;2000-04
10 LI Shu-lian, WANG Xiao-hong, XUE Lin, LIN Jing, ZHAO Chun-yu, TANG Chao-shu (Institute of Cardiovascular Research, The First Hospital, Beijing University, Beijing 100034, China) [;Changes of metallothionein contents in plasma and tissues of rabbit with atherosclerosis[J];中国病理生理杂志;2000-07
【Secondary References】
Chinese Journal Full-text Database 9 Hits
1 ZHANG Jia-yu;LIU Li-li;LI Guo-chao;YU Kai-min;LV Peng;YAN Yan-chun;Graduate School, Chinese Academy of Agricultural Sciences;;Oxidative stress effects of chlorpyrifos on zebrafish embryos[J];中国环境科学;2016-03
2 Zhang Yan;Wang Keyue;Department of Toxicology,School of Public Health,Zunyi Medical University;;Effects of continuous administration of cadmium from the parental generation to first filial generation on lipid peroxidation damage in rats[J];遵义医学院学报;2014-06
3 Wei Sheng;Qiao Mingqi;Shandong University of Traditional Chinese Medicine;;The Main Problems,Research Progress and Prospect of the Function Mechanism of Liver[J];陕西中医学院学报;2014-03
4 SHI Xiao-wei 1,SHEN Yong-wei 2,ZHOU Xue-lan 1 School of Physical Education,Hainan Normal University,Haikou 571158,China,;Metallothionein and Exercise[J];体育科技文献通报;2013-09
5 Yin Zhihong,Pang Quanhai(College of Animal Science and Veterinary Medicine,Shanxi Agricultural University,Taigu Shanxi 030801,China);Effect of Molybdenum on the Morphology of the Liver and Kidney in Chickens[J];山西农业大学学报(自然科学版);2012-05
6 WANG Shun-rong,CHEN Rong,ZHANG Chun-mei,et al.Luzhou Medical College,Luzhou,Sichuan 646000,China;Protective effect of chitosan oligosaccharide against acute renal failure induced by mercuric chloride[J];四川医学;2012-09
7 XIE Hui-fang,WU Shun-hua,ZHANG Jie,et al.College of Public Health of Xinjiang Medical University,Urumqi,Xinjiang 830011,China;Association between MT2A Gene Polymorphism and Water-Born Endemic Arsenism in Xinjiang[J];环境与健康杂志;2011-02
8 XIAO Jie,CUI Heng-min*,YANG Fan,PENG Xi,CUI Wei,CHENG An-chun,CHEN Tao,BAI Cai-min(Key Laboratory of Environmental Hazard and Animal Diseases of Sichuan Province,College of Veterinary Medicine,Sichuan Agricultural University,Ya'an 625014,China);Effect of High Molybdenum on the Pathologic Lesion and Antioxidative Function of Kidney in Broilers[J];畜牧兽医学报;2010-12
9 JIA Xiuying,SHI Cailei,LIU Xiaoxu College of Life and Environmental Science,Hangzhou Normal University,Hangzhou 310036,China;Effects of Cadmium on oxidative stress and metallothionein of liver in frog Rana nigromaculata[J];生态学报;2010-02
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