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《JOURNAL OF BEIJING MEDICAL UNIVERSITY》 1998-04
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LOCALIZATION AND QUANTIFICATION OF LAMININ AND LAMININ RECEPTOR IN THE HUMAN PLACENTAL VILLI

CUI Cailian, LI Ying(Department of Histology and Embryology, Beijing Medical University, Beijing 100083)Keywords Laminin Laminin receptor Localization Quantification Human placental villi  
ABSTRACT Objective: To study the localization and quantification of laminin (LN) and laminin receptor (LNR) in the human placental villi during early, middle and term pregnancy. Methods: LN and LNR in the human placental villi was measured using immunohistochemical ABC method and Q500 image analysis system. Results: LN positive immunostaining was found in placental villous epithelial basement membranes and vascular endothelial basement membranes. LNR positive immunoreactive substance was localized in the villous epithelial cellular plasma (including cytotrophoblast and syncytiotrophoblast ) and syncytiotrophoblastic cellular surfaces, but not in the nucleus. Along with placental development, the amount of LN and LNR decreased gradually. Conclusion: LN and LNR exist in the human placental villi, and their relative content decreased following the placental growth.
【Fund】: 国家自然科学基金
【CateGory Index】: R329.1,
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