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《JOURNAL OF BEIJING MEDICAL UNIVERSITY》 1998-05
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THE EFFECTS OF THREE KINDS OF ANTIOXIDANT ON THE BIOLOGICAL EFFECT OF HEL CELLS INDUCED BY Cr 6+

JIA Guang #, MA Ning, WANG Naifen, WANG Xiaoyan, XU Houen, LIU Shijie (#Department of Occupational Health, Beijing Medical University, Beijing 100083)  
Objective: To study the effect of Vit C and glutathione (GSH) and Qin Mei KFJ on the cytotoxicity and DNA damage and the valent state of chromium in human embryo lung(HEL) cells induced by K 2Cr 2O 7(Cr 6+ ). Methods: Thiazolyl blue tetrazolium bromide (MTT) method and single cell gel electrophoresis (SCGE) and atomic absorption were adopted to study the cytotoxicity and DNA damage and the valent state of chromium. Results: Qin Mei KFJ could antagonize the cytotoxicity induced by K 2Cr 2O 7 effectively, however, Vit C and GSH play a different role according to the different doses of K 2Cr 2O 7 used, respectively. Conclusion: Qin Mei KFJ could promote the reduction of extracellular Cr 6+ and decrease the uptake of Cr 6+ by cells, but Vit C and GSH possessed complicated action, respectively.
【Fund】: 卫生部科学研究基金
【CateGory Index】: R965
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