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《JOURNAL OF BEIJING MEDICAL UNIVERSITY》 1999-03
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Repeated injection of low dose ketamine for the treatment of acute period of adjuvant arthritic inflammatory pain

WANG Yun #, HUANG Cheng, CAO Yu, HAN Ji Sheng (#Neuroscience Research Institute, Beijing Medical University, Beijing 100083)  
Objective: To observe the effect of repeated subcutaneous injection of ketamine for the treatment of acute period inflammatory pain. Methods: Rats with ankle monoarthritis were given subcutaneous injection of ketamine, once a day, 5 times per week for a total of 4 weeks. Scores of pain were tested by dorsal flexion of ankle joint. Increase percentage of body weight was taken as an index of general condition, and the degree of swelling was expressed by the change of circumference of ankle. Results: (1) Subcutaneous injection of ketamine (0.08, 0.4, 2, 10 mg·kg -1 ), produced significant analgesia in arthritic rats at the dose of 10 mg·kg -1 starting from the 2 nd week; both 2 mg·kg -1 and 10 mg·kg -1 ketamine produced significant analgesia starting from the 3rd week ( P 0.05 and P 0.01, respectively). (2) Repeated administration of ketamine produced a mild reduction of the circumference of arthritic ankle ( P 0.05). (3) The body weight of the rat was not affected by long term administration of ketamine. Conclusion: Repeated substaneous injection of ketamine for 4 weeks significantly reduces inflammatory pain in the acute period of adjuvant monoarthritis, without significant aversive side effects.
【Fund】: 国家自然科学基金
【CateGory Index】: R593.22-332
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【Co-references】
Chinese Journal Full-text Database 5 Hits
1 TANG Zhao liang, SONG Xiao ge , ZHANG Fu qing,HOU Zheng ming, CHEN Quan zhu, LIU Xian hua(Institute of Acupuncture and Moxibustion,Anhui College of Traditional ChineseMedicine, Anhui Hefei 230038, China);Experimental Study on Anti-inflammatory andImmunological Mechanism of Moxibustion[J];Journal of Anhui Traditional Chinese Medical College;2003-02
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3 ZHOU Jialing,ZHU Qi.Department of Rheumatology,Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai 200052, China;Effects of acupuncture on the rheumatoid arthritis[J];CHINESE JOURNAL OF RHEUMATOLOGY;2000-03
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5 ZHANG Lu-fen1,YAN Ming-ru1,CHENG Jin-lian2,et al(1 School of Acupuncture and Moxibustion,Beijing University of Chinese Medicine,Beijing 100029;2 Beijing Hospital of Traditional Chinese Medicine);Effect of acupuncture on β-EP levels of plasma,hypothalamus, pituitary and lymph node in rats with adjuvant-induced arthritis[J];Journal of Beijing University of Traditional Chinese Medicine;2007-01
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