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《Packaging and Food Machinery》 2011-05
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Study on Sedative and Hypnotic Effects of Fat-soluble Alkaloids in Eucommia Male Flowers

LI Xin,LIU Yan,FAN Jin-ling,LUO Lei,GUO Han(Food and Bioengineering College,Henan University of Science and Technology,Luoyang 471003,China)  
Objective: Study the sedative and hypnotic effects of fat-soluble alkaloids of Eucommia male flowers with different dose.Methods: The fat-soluble alkaloids were extracted from the Eucommia male flowers in acid.We investigated the effects on spontaneous activity of mice,the synergistic effect with pentobarbital sodium,and anticonvulsant effects of fat-soluble alkaloids in Eucommia male flowers with different dose.Results: Fat-soluble alkaloids of Eucommia male flowers could significantly inhibit the spontaneous activity;enhance the action on mice sleeping ratio and prolong the sleeping time of pentobarbital sodium with subthreshold dose;prolong the sleeping time and shorten the sleeping latency of pentobarbital sodium with superthreshold dose;effectly reduce the eclamptic ratio of mice.Conclusion: Fat-soluble alkaloids of Eucommia male flowers possess obviously sedative and hypnotic effects in mice.
【Fund】: 河南省教育厅自然科学基金项目(2006550001);; 河南科技大学科研创新能力培育基金(2009CZ0015)
【CateGory Index】: S567.19
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