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《Journal of Binzhou Medical College》 2004-03
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CHANGES OF THE CONCENTRATIONS OF SERUM IL-8,IL-10 AND NSE IN NEONATES WITH HYPOXIC-ISCHEMIC ENCEPHALOPATHY AND THEIR CLINICAL SIGNIFICANCE

HAN Ruimin,FENG Xuebin,GAO Lejun, et al (Department of Pediatrics,Affiliated Hospital of Binzhou Medical College,Binzhou 256603,China)  
Objective:To evaluate the dynamic changes of IL 8,IL 10 and neuron specific enolase(NSE) in neonates with hypoxic ischemic encephalopathy(HIE) and their clinical significance to provide basis for the diagnosis,therapy and prognosis of HIE.Methods:Thirty five cases of infants with HIE were selected and divided into three groups according to the severity of the patients' condition,with 20 cases of healthy newborn babies as control group.Peripheral venous blood in the acute and restorative stags of the HIE group was collected and that of the control group at the first day after birth.The dynamic changes of serum IL 8,IL 10 and NSE were measured by RIA and ECLI .Results:The HIE group's levels of IL 8 and NSE are higher in the acute stage than those in the control group( P 0 05),while the lever of IL 10 is obviously lower than that in the control group( P 0 05).There are significant differences between the levels of IL 8,IL 10 and NSE with different severity in acute stage of HIE.The levels of IL 8 and NSE in the severe HIE group are obvioulsy higher than those in the light and moderate HIE goups ( P 0 05),while the level of IL 10 in the severe HIE group is lower than that in the light and moderate HIE groups ( P 0 05).The levels of IL 8 and NSE are still higher in the restorative stage than those in the control group( P 0 05),while the level of IL 10 is still lower than that in the control group ( P 0 05).The concentration of serum NSE has a positive correlation with IL 8,but has a negative correlation with IL 10.Conclusion:IL 8,IL 10 and NSE may be involved in the occurrence and deveplopment of HIE.The levels of IL 8,IL 10 and NSE are closely correlated with the severity of HIE.
【CateGory Index】: R722.1
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【References】
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1 LIU Xiuqin,WANG Guanqi,SUN Ruopeng (Qingdao Municiple Hospital,Qingdao 266000);THE VALUE OF NSE AND VIDEO-EEG FOR DIAGNOSIS OF EPILEPSY AND PSEUDO-EPILEPSY IN CHILDHOOD[J];Journal of Binzhou Medical College;2004-05
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