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《Journal of Binzhou Medical College》 2004-04
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SHI Zengli,LIU Feng,YU Xiaoling, et al (Department of Pathophysiology,Binzhou Medical College,Binzhou 256603)  
Objective:To detect the changes of facilitative inflammatory cell factors (IL 8,TNF α) in blood plasma and inflammatory cells in peripheral blood and abdominal effusion at different periods of time in septicemic rats.Methods:Septicemia models were replicated by means of cecum ligature puncture,the levels of IL 8 and TNF α were measured by enzyme linked immunosorbent assay (ELISA) and the leucocytes in peripheral blood and abdominal effusion were counted under microscope after rats' blood and abdominal effusion were taken at 0,8 and 16 hours post experimentally.Results:In septicemia group,levels of IL 8 and TNF α at 8 and 16 hours after the experiment were noticeably higher than those at 0 hour ( P 0 01) post experimentally with that at 8 h more evident;IL 8 and TNF α levels of septicemia group at 8 and 16 hours were obviously higher than those of control group on which sham operations were done ( P 0 05).The number of leucocyte in peripheral blood of septicemic rats at 8 and 16 hours post experimentally was much lower than that at 0 hour ( P 0 01) with a trend of progressive decrease ,and the number in abdominal effusions had a trend of progressive increase ( P 0 01).Conclusion:IL 8 and TNF α may play a major role in the course of rats' septicemia and the abnormal distribution of inflammatory cells of septicemic rats is closely related to IL 8 and TNF α.
【CateGory Index】: R5153
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