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《Journal of Binzhou Medical College》 2006-04
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Effects of astragalus on serum and liver tissue TGF-β1 level in immature rats with obstructive jaundice

LI Baowen ZHANG Lan LV ZenghuaDepartment of Surgery,Binzhou Medical College,Binzhou 256603  
Objective To investigate the effects of astragalus on serum and liver tissue TGF-β1 level in immature rats with obstructive jaundice(OJ).Methods Forty immature male Wistar rats were randomly divided into normal control group,sham operation group,OJ group,OJ+astragalus group.In OJ+astragalus group,astragalus(250 mg/100 g body weight) were given for 7 days.The content of TGF-β1 in serum and liver tissue in rats was detected by ELISA.Results The level of serum TGF-β1 was higher in OJ group and OJ+astragalus group than that in normal control group and sham group.The level of TGF-β1 of liver tissue in OJ+astragalus was lower in than that in OJ group.The morphologic changes of the liver ameliorates in OJ+astragalus group.Conclusion The astragalus helps to improve the liver morphology,decreases the process of liver fibrosis in immature rats with obstructive jaundice.
【Fund】: 山东省中医药科技发展计划项目(2005-002)
【CateGory Index】: R285
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