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《Journal of Binzhou Medical University》 2012-05
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Expression and significance of macrophage migration inhibitory factor in ARDS induced in intestinal ischemia-reperfusion

WANG Weichen1 XIA Yongfu2 HU Yejia1 1 Department of Pathophysiology,Binzhou Medical University,Yantai 264003; 2 Department of Respiratory Medicine,Affiliated Hospital of Binzhou Medical University  
Objective Establishment of intestinal ischemia-reperfusion model of acute respiratory distress syndrome(ARDS),observation of expression of macrophage migration inhibitory factor(MIF) in serum and lung tissue and discussion of significance of MIF in the model group.Methods 40 healthy male SPF SD rats were randomly divided into control group(10 rats),intestinal ischemia group(10 rats) and intestinal ischemia-reperfusion group(20 rats).In the intestinal ischemia-reperfusion group,the rats with screening respiratory rate 28 beats / min,and PaO2 ≤(60 mmHg) PaCO2 35 mmHg were included.To examine the changes of MIF in serum,these lung tissue were fixed with 4% paraformaldehyde for 24 h,then embedded in paraffin,made to 5μm slices.MIF expression in lung tissue was measured by immunohistochemistry.Results MIF concentration in the serum of model group was significantly higher(P0.01),the immunohistochemical expression of lung tissue was significantly increased(P0.01).Conclusion Higher probability of occurrence of ARDS caused by intestinal ischemia-reperfusion injury is associated with increased expression of MIF in serum and lung tissue,it may be one of the important mechanisms of ARDS in multiple organ dysfunction caused by injury in immune and inflammatory response induced in intestinal ischemia-reperfusion.
【Fund】: 滨州医学院科技计划(BY2009KJ07)
【CateGory Index】: R363
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