Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Binzhou Medical University》 2012-05
Add to Favorite Get Latest Update

Expression and significance of macrophage migration inhibitory factor in ARDS induced in intestinal ischemia-reperfusion

WANG Weichen1 XIA Yongfu2 HU Yejia1 1 Department of Pathophysiology,Binzhou Medical University,Yantai 264003; 2 Department of Respiratory Medicine,Affiliated Hospital of Binzhou Medical University  
Objective Establishment of intestinal ischemia-reperfusion model of acute respiratory distress syndrome(ARDS),observation of expression of macrophage migration inhibitory factor(MIF) in serum and lung tissue and discussion of significance of MIF in the model group.Methods 40 healthy male SPF SD rats were randomly divided into control group(10 rats),intestinal ischemia group(10 rats) and intestinal ischemia-reperfusion group(20 rats).In the intestinal ischemia-reperfusion group,the rats with screening respiratory rate 28 beats / min,and PaO2 ≤(60 mmHg) PaCO2 35 mmHg were included.To examine the changes of MIF in serum,these lung tissue were fixed with 4% paraformaldehyde for 24 h,then embedded in paraffin,made to 5μm slices.MIF expression in lung tissue was measured by immunohistochemistry.Results MIF concentration in the serum of model group was significantly higher(P0.01),the immunohistochemical expression of lung tissue was significantly increased(P0.01).Conclusion Higher probability of occurrence of ARDS caused by intestinal ischemia-reperfusion injury is associated with increased expression of MIF in serum and lung tissue,it may be one of the important mechanisms of ARDS in multiple organ dysfunction caused by injury in immune and inflammatory response induced in intestinal ischemia-reperfusion.
【Fund】: 滨州医学院科技计划(BY2009KJ07)
【CateGory Index】: R363
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Qiujin  , SHEN Hong, ZHANG Wei, LI Yinping, LI Tanshi.  EmergencyDepartment, General Hospital of PLA, Beijing 100853, China;Effects of combined naloxone and methylprednisolone on nuclear factor-κB expression in the lung in acute lung injury in rats[J];Chinese Critical Care Medicine;2005-06
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 WEI Yun-wei,SHAO Dong-hua,GE Jia-xi,PU Jian-feng,WANG Hong (Department of Anesthesiology,the Affiliated People's Hospital of Jiangsu University,Zhenjiang 212000,China);Effect of LPS-induced acute lung injury in mice by mildronate[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2012-04
2 YANG Wen1,DING Yun-ping2,LIU Xue-xu1 (1.Laboratory Animal Center of Sichuan University,Chengdu 610041,China;2.State Key Laboratory of Oral Diseases,Sichuan University,Chengdu 610041,China);Measurement of KM Mice Respiratory Organ Parameters and Intratracheal Injection Tolerance[J];Sichuan Journal of Zoology;2011-03
3 SU Zhao-jie, JIANG Yi, LV Li-zhi.Clinical Medical School of Fuzhou General Hospital of Nanjing Military Area, Fujian Medical University, Fuzhou 350025, China;Impact of retrograde perfusion in autologous orthotopic liver transplantation on acute lung injury in rats[J];Organ Transplantation;2012-05
4 GUO Zhengming1,CHEN Yi2,LIU Huijun2,XIAO Yuequn1,SONG Haipeng1,WANG Zhaozhao1,QU Xiaolin1,LUO Ziqiang2(1.Department of Basic Science,Hunan Traditional Chinese Medicine College,Zhuzhou Hunan 412012;2.Department of Physiology,Xiangya School of Medicine,Central South University,Changsha 410078,China);Ginkgo biloba extract (Ginaton) attenuates acute lung injury induced by lipopolysaccharide in mice[J];International Journal of Pathology and Clinical Medicine;2009-04
5 GE Dong-jian1,LIU Gong-jian2(1.Jiangsu Province Key Laboratory of Anesthesiology;2.Dept of Anesthesiology,Affiliated Hospital,Xuzhou Medical College,Xuzhou Jiangsu 221002,China);Inhibition of the PTEN protects rats against LPS-induced acute lung injury[J];Chinese Pharmacological Bulletin;2010-09
6 DAI Tian1,CAO Shu-hua2.(1.Graduated School of Tianjin Medical University,Tianjin 300070,China;2.Department of ICU,Tianjin First Center Hospital,Tianjin 300020,China);The Roles of Cytokines in Acute Lung Injury/Acute Respiratory Distress Syndrome[J];Medical Recapitulate;2008-06
7 GAO Dong-na,ZHANG Yu.Department of Emergency,the First Affiliated Hospital,Dalian Medical University,Dalian 116001,China;Development of acute lung injury[J];Chinese Journal of Critical Care Medicine;2008-01
8 WANG Jin~1 YANG Guang-tian~1 QIAO Li-fen~2 LI Yong-sheng~1.①Department of Emergency;②Department of Respiratory Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China;Effects of Xingnaojing injection (醒脑静注射液) on lipopolysaccharide-induced nuclear factor-kB activation and cytokine production in rat alveolar macrophages[J];Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care;2008-04
9 NAN Yong,CHEN Jin-chun,HE Guo-xin,LUO Wen-chao,HU Yong-qi(Ruian People Hospital,Ruian 325200,China);Protective effect of ulinastatin plus methylprednisolone on endotoxin-induced acute lung injury in rats[J];Chinese Journal of New Drugs;2009-11
China Proceedings of conference Full-text Database 1 Hits
1 Gao Dong-na,Zhang Yu First Affiliated Hospital;Dalian Medical University;Dalian 116001;China;;The Development Of Acute lung injury[A];[C];2009
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 GUO Zhenhui,HONG Xin,MAO Baoling,et al. 1Department of Respiratory,Guangzhou General Hospital of Guangzhou Command,Guangzhou 510010;The role of nuclear factor-κB activation in acute lung injury induced by sepsis[J];CHINESE CRITICAL CARE MEDICINE;2000-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved