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《Journal of Chengdu Medical College》 2010-04
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Clinical observations of Endostar combine with chemotherapy injection on advanced non-small cell lung cancer

WANG Qiang,PATIGULI Aerxidin,ZHANG Yan(First division of Internal Medicine,The Affiliated Xinjiang Tumor Hospital,Xinjiang Medical University,Urumchi 830011,China)  
Objective To observe the clinical effects of Endostar combined with chemotherapy injection in patients with advanced non-small cell lung cancer(NSCLC).Methods Thirty-two patients with advanced non-small cell lung cancer who were definite by pathohistology or cytology,which received the treatment of Endostar combine with chemotherapy injection.Add Endostar injection 15mg into physiological saline 500 ml and vein intravenous drip brady-equally 3-4 hours for 14 days.Meanwhile,combining chemotherapeutic drugs that chemotherapy with platinum-based.Every 21 days is a periodicity to estimate efficacy and safety.Results Thirty patients displayed the to display curative effect and obtained that 0 CR,15 PR,11 SD and 4 PD,the objective response rate was 50% and disease control rate was 86.67%.The main toxicity is related to chemotherapeutics including cardiac toxicity related with Endostar.Conclusion Endostar combine with chemotherapy injection on advanced non-small cell lung cancer can improve efficacy with good safety.And we should give more attention during treatment with recombinant human endostatin combined with chemotherapy.
【CateGory Index】: R734.2
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