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《Journal of Chengdu Medical College》 2011-04
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Application of marine collagen peptide in dialysis patients

YANG Chang-qing1,CAI Mu-yi2,PAN Xing-chang2,GU Rui-zeng2,HU Wen1(1.Clinical Nutrition Department of West China Hospital of Sichuan University,Chengdu,Sichuan 610041,China;2.China National Research Institute of Food & Fermentation Instruries,Beijing 100027,China)  
Objective To observe the effect of marine collagen peptide on nutrition,liver and kidney function,and immunity of patients with maintenance dialysis.Methods Fifty patients with maintenance hemodialysis were selected and randomized into two groups: intervention group and control group.Patients in the intervention group were administrated with marine collagen peptide by 20 g/d,and in the control group with whey protein by 20 g/d.The treatment last for 15 days.The liver and kidney function,nutritional status and immune function were compared between two groups after responsive treatment.Results Thirty-eight patients were evaluated at the end of study,21 patients in the intervention group and 17 patients in the control group.There was no significant improvement in albumin,blood lipids,hemoglobin(P0.05),but significant decrease in total protein,urea,creatinine and significant increase in alanine aminotransferase(ALT)(P0.05) in the intervention group after treatment.All indicators in control group showed no significant differences(P0.05)compared to baseline.There was a significant different in aspartate aminotransferase(AST) between two groups after treatment.Immunoglobulin showed no significant increase(P0.05)compared to baseline in two groups after treatment.There was a significant increase(P0.05)in IgG in the intervention group compared to the control group,but no significant difference in IgM and IgA(P0.05).Conclusions Marine collagen peptide has a better improvement on liver and kidney function,immune function than whey protein in maintenance dialysis patients.
【Fund】: 科研院所技术开发研究专项资金资助项目(2008EG111007)
【CateGory Index】: R459.5
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