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《Journal of Chengde Medical College》 2001-03
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OBSERVATION OF THE DYNAMIC CHANGEIN THE HIPPOCAMPAL SOD ACTIVITY AND MDA CONCENTRATION IN ISCHEMIA REPERFUSION RAT

LANG Zhi feng,GAO Wei juan,YUAN Guo hong,et al (Department of physiopathology,Chengde Medical College,Hebei Chengde 067000,China)  
Objective:To observe the dynamic change in the hippocampal SOD activity and MDA concentration in ischemia reperfusion rat.Methods:The model of ischemia reperfusion injury was performed based on hypotension.After creating the model the rat were all decapitated and extract the brain to assay the hippocampal SOD activity and MDA concentration on the 1 st day,7 th day and 15thday.Results:In model group aSOD achtivity significent ydecrease (P0.05),and on the 15 th day have some increase compared with on the 1 st day.MDA concentration significently increase in model group,and there isn't patent difference among all the model groups.Conclusion:the significent change in the hippocampal SOD activity and MDA concentration in ischemia reperfusion rat indicated that free radical reaction had participated in the ischemia reperfusion injury.
【CateGory Index】: R363
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