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《Journal of Chengde Medical College》 2002-01
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THE CLINICAL INVESTIGATION OF ADAPTIVE IMMUNE THERAPY IN OVARIAN CANCER

LI Rui min,XU Da wei,ZHENG Jian jun,et,al (Department of Microbiology and Immunology,Chengde Medical College, Hebei Chengde,067000,China)  
Objective:To investigate the effect of adaptive immune therapy on ovary cancer.Methods:Small doses of rIL 2 were used through in vitro for induction and proliferation to the tumor infiltrating lymphocytes of the fluid in the abdominal cavity on the 22 victims of ovary cancer,and the level of IL 2R and cell killing activity were tested before and after the proliferation.Then observation is conducted on the CA125 level of the pathological cell and serum in abdomen when they were in dynamic state before and after the therapy.Results:It turned out that activity of CD8,CD16 and NK cells was going up markedly,and at the same time the level of CA125 was going down,but to different degree in the 22 cases in question,of which,the pathological cells of the fluid in the abdominal cavity disappear 68.50% of the fluid in the abdominal cavity disappear after TIL and rIL 2 treatment on part and the whole of the body,the total effectiveness reached 81.2%.and no by effect was found in the post visit during the period of 1 to 8 months.Conclusion:Adaptive immune therapy has visible effect on the ovary cancer. [
【CateGory Index】: R737.31
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