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《Journal of Chengde Medical College》 2005-03
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STUDY ON THE EXPRESSION OF IL-6, IL-6R AND APOPTOSIS-ASSOCIATED GENES IN GASTRIC CARCINOMA

ZHAO Xiang-yang, LI Yu-hong, XU Qian, et al(266 Hospital of Chinese People's Liberation Army, Hebei Chengde 067000, China)  
Objective: To study the expression of IL-6 and its receptor(IL-6R), Fas, FasL and Bcl-2 in normal gastric mucosas, precancerous lesion, gastric carcinoma,and to explore their clinical significance. Methods: The expression of IL-6 and IL-6R mRNA were detected by means of In situ hybridization(ISH), the expression of Fas,FasL and Bcl-2 were detected by means of immunohistochemical technique. Results: The positive rates of IL-6 and IL-6R were significantly different between normal gastric mucosas and precancerous lesion(P0.05),and there were significant difference between precancerous lesion and early gastric carcinoma(P0.05). The levels of Fas expression in gastric carcinoma were obviously lower than those in both normal mucosas and precancerous lesion (P0.05). Significant difference of FasL expression were found both between normal mucosas and precancerous lesion and between precancerous lesion and gastric carcinoma(P0.05). There was significant difference for expression of Bcl-2 between normal gastric mucosas and both precancerous and gastric carcinoma(P0.05). Conclusions: IL-6 and its receptor are two important indexes that reflect the occurrence and development of gastric carcinoma.In clinical,it would be a effective means to heal gastric carcinoma by adjusting Fas,FasL and Bcl-2.
【CateGory Index】: R735.2
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