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《Journal of Chengde Medical College》 2008-04
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EFFECTS OF SERICINE ON BLOOD SUGAR OF TYPE 2 DIABETES MELLITUS RAT MODEL

FU Xiu-mei MA Bao-jun Zhao Li-jun et al (Chengde Medical College,Hebei Chengde 067000,China)  
Objective:To study the effects of extract of silk cocoon-sericine on blood glucose(BG)of type 2 diabetes mellitus rat model.Methods:48 male SD rats were randomly divided into 4 groups(n=12):normal control group,diabetes model group,sericine treatment group and sericine prevention group.The rats in diabetes model group,sericine treatment group and sericine prevention group were intraperitoneally injected Streptozotocin (STZ)to establish type 2 diabetes rats model.After the models were successfully established,the rats in model group were not given any treatments;the rats in sericine treatment group were lavaged with sericine(2.4g/kg/d) for 35 days;the rats in sericine prevention group were lavaged with sericine(2.4g/kg/d)for 35 days before establishing diabetes rat model.Results:The BG of rats in diabetes model group was obviously higher than that of the rats in normal control group(P0.01).After being treated with secricine,the BG of diabetes rat model decreased significantly(secricine treatment group compared with diabetes model group:P0.01)and approach to normal rats(secricine treatment group compared with normal control group:P0.05).There had no obvious difference between the BG of rats in secricine prevention group and in normal control group(P0.05),while the BG of rats in secricine prevention group were significantly lower than that of rats in diabetes model group(P0.01).Conclusions:Sericine can decrease the BG of diabetes rats and can prevent increasing of BG in diabe- tes mellius.
【Fund】: 河北省教育厅项目(2006301,2007324);; 河北省科技厅项目(08276101D-19)
【CateGory Index】: R587.1
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【References】
Chinese Journal Full-text Database 1 Hits
1 FU Wen-liang, HE Ya-qiang, FU Xiu-mei, et al (Chengde Medical College, Hebei Chengde 067000, China);EFFECTS OF SERICINE ON PCNA EXPRESSION OF SPERMATOGENIC CELLS IN TYPE 2 DIABETES MELLITUS RATS TESTIS[J];Journal of Chengde Medical College;2009-04
【Co-references】
Chinese Journal Full-text Database 1 Hits
1 Qi Zhong LIU, Li Quan HU (Institute of Urology & Andrology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, China);Advances in Etiology of Diabetes Mellitus and Erectile Dysfunction[J];Acto andrologica Sinica;2002-03
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