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《Journal of Chengde Medical College》 2013-05
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CHANGES OF HDL-C AND LDL-C OF DIABETIC RATS AND REGULATORY EFFECTS OF SERICIN

YANG Zhen-jun;ZHANG Yan;HOU Li-na;Department of Human Anatomy,Chengde Medical College;  
Objective:To investigate the regulatory effects of sericin on low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) of type 2 diabetic rats.Methods: 48 male SD rats were randomly divided into normal control group,diabetes model group,sericin treatment group and positive control group(n=12). Streptozotocin(25mg/kg) was injected into the peritoneal cavity for 3 days(one time a day) to establish type 2 diabetes rats model. Then the rats in model group received no more treatments; the rats in sericin treatment group were lavaged sericin(2.4g/kg/d) for 35-day; the rats in positive control group were lavaged metformin(55.3mg/kg/d) for 35-day. The blood glucose,HDL-C and LDL-C of rats in each group were respectively detected.Results:Compared with rats in normal control group,the blood glucose and LDL-C of rats in model group increased obviously,while HDL-C decreased obviously(P 0.01,P 0.05). Compared with rats in model group,the blood glucose and LDL-C of rats in sericin treatment group and positive control group decreased signifi cantly,while HDL-C increased signifi cantly(P 0.01). Conclusions: Sericin can obviously improve lipid disorder of diabetes mellitus by increasing HDL-C and decreasing LDL-C.
【Fund】: 河北省自然科学基金项目(H2012406018 H2013406096)
【CateGory Index】: R587.1
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【Co-citations】
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