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《Journal of Chengdu Unversity of Tarditional Chinese Medicine》 2002-04
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Influence on Traditional Chinese Medicine of Dispelling Phlegm to Eliminating Stagnation to Expression of MMP_2 in MKN-45 Gastric Carcinoma Tissue on Nude Mouse

XIAO Yan, WEI Ping kang, XU Ling, et al Changzheng Hospital, The Second Military Medical College (Shanghai,200003,China)  
Objective:To observe the influence on traditional Chinese medicine of dispelling phlegm to eliminating stagnation to expression of MMP 2 in MKN-45 gastric carcinoma tissue on nude mouse and explore the mechanism of TCM inhibiting the infiltrative metastasis of gastric carcinoma. Methods:The MKN-45 human gastric carcinoma on nude mousewas made and detected the expression of MMP 2 in gastric carcinoma tissue by immunohistochemistry S-P method. Results:There was a statistically significant difference between the model group and the treatment group(P0 05). Conclusion: The mechanism of traditional Chinese medicine of dispelling phlegm to eliminating stagnation inhibiting the infiltrative metastasis of gastric carcinoma probably related with it can affect the expression of matrix metalloproteninse and decrease the degradation of extracellular matrix and basement membrane.
【Fund】: 上海市卫生局科研基金资助项目
【CateGory Index】: R273
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