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Enhanced Synapstic Plasticity in Parkinson's Disease Mice Sunbstantla Nigra by Electroacupuncture Therapy

TANG Yong, YU Shu-guang,CHEN JinAcupuncture & Tuina college, Chengdu University of Traditional Chinese Medicine,(Chengdu,610075,China)  
Objective To determine whether electroacupuncture (EA) treatment enhance synaptic morphologic plasticity in Parkinson's disease (PD) mice substantia nigra compacta(SNC). Male mice(C57BL/6J) were averagely and randomly divided into controlled group,controlled EA group, model group and EA group. PD model mice were induced by i.p. 1-methyl,4-phenyl-1,2,3,6 tetrahydropyridine. We take EA treatment with frequency from 2 to 100HZ,volt arrange from 2 to 4V,points on Hegu(LI4) and Taichong(LV3).The treatment was once daily. After 21 times treatments, we killed all mice and observed synapse plasticity in SNC by electron microscope. The positive cell of nissles stain in PD mouce increased after electroacupuncture; the number and the number density increased in substantial nigra compared with PD, the volume density also enlarged. [Conclusion] EA has a trendency to enhance degenerative dopaminergic neuron plasticity which need to study in depth.
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