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《Journal of Chengdu Unversity of Tarditional Chinese Medicine》 2005-02
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The Effect of Total Saponin of Panax Ginseng and Panaxquinquefoliuml Saponin on Hematopoiesis in Anemic Mice

ZHU Bi-de,LV-Yan , FENG Xue-mei(1.School of basic medical sciences and forensic medical sciences ,University of Sichuan,Sichuan Chengdu 610041; 2.Department of biochemistry and molecule biology, School of basic medical sciences, Chengdu University of traditional Chinese medicine Chengdu 610075)  
Objective: TO compare the effect of PNS on hematopoiesis in anemic mice with that of TSPG。 Methods: Anemic mice model resulted from myelosuppression by irradiation and cytotoxic chemotherapeutic compounds were randomly divided into three groups: modle control group,TSPG treatment group,PNS treatment group。hematopietic progenitor cells culture in vitro and peripheral blood count were used to detect the numbers of peripheral blood cells and CFU-GM ,CFU-E/ BFU-E and CFU-Meg. Results: Both of TSPG and PNS could significantly promote the rise of RBC,HB(P0.05)and BMC(P0.01).TSPG and PNS showed adverse effect on WBC. TSPG could slightly increase the numbers of WBC(P0.05), while PNS decreased it in anemic mice(P0.05). Concentration of TSPG between 25-100μg/ml could promote the proliferation of CFU-GM ,CFU-E/ BFU-E and CFU-Meg. The optimal concentration for growth of CFU-E/ BFU-E and CFU-Meg was 25μg/ml and the optimal concentration for growth of CFU-GM 50μg/ml.Concentration of PNS between 25-100μg/ml had an positive influence on erythropoiesis and magakaryopoiesis. Though PNS in low concentration( 25-50μg/ml) showed no obvious effect on the growth of CFU-GM ,high concentration of PNS(100μg/mL )could suppress the growth of CFU-GM. Conclusion: Both of PNS and TSPG can promote hematopoiesis in anemic mice though they act in different way.
【Fund】: 国家自然科学基金资助(批准号:30271661)
【CateGory Index】: R285
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