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《Journal of Chengdu Unversity of Tarditional Chinese Medicine》 2005-03
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Influence of Chai-hu Hemostatic on Dynamic Regular Patterns of Endothelin and Nitrogen Monoxidum in Uterus of Rats Inserted Intrauterine Device

ZHOU Yi, CHEN Gang, SHENG Yin -jun , et al (Chengdu University cf Traditional Chinese Medicine, Sichuan, 610075, China)  
Objective:To seek for the dynamic regular patterns of endothelin(ET) and nitrogen monoxidum(NO), after Chai-hu hemostatic affused in the rats whose uterus were located by IUD (intrauterine device), finding clearer mechanism of IUD side- effects in order to provide better ideas for clinical treatment. Method: Make an investigation after developing rats IUD models, and establishing manual estrous-cycle rats models and testing keratinocyte ratio of vagina epithelia, and determining estrogen and progesterone of rats' uterus organism blood serum; testing dynamic movement of ET-1, NO of Cu-IUD rats' uterus organism in manual estrous-cycle and Chaihu hemostatic effects. Results: Comparing manual estrous-cycle Rats Models to Normal Models, there were not obvious differences in the level of estrogen and progesterone. After located IUD in rats' uterus, ET-1 raised in the early cycle , but it lowed in the later cycle; After the IUD was located, NO in the whole of the cycle raised much than normal, so that, Chaihu hemostatic could low NO exudation. Conclusion: Established manual estrous-cycle rats models were effected; After we located IUD in rats' uterus, IUD made effects in the dynamic movements of ET-1,NO of rats' uterus organism, however, Chaihu hemostatic could confront side-effects from the IUD.
【Fund】: 国家自然科学基金资助项目(批准号:A30171134)
【CateGory Index】: R285;
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