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Incrased Expression of Dopamine Transporter in Parkinson's Disease Mice Substantia Nigra by Electroacupuncture Therapy

ZHANG Li~1,TANG Yong~(2,3),YU Shu-guang~3(1.Clinical Department,Medical College,Tibet University,850000;2.Institute of Biomedical Engineering,West China Center of Medical Science,Sichuan University,610041;(3.Chengdu University of Traditional Chinese Medicine,610075)  
Objective:To determine whether electroacupuncture(EA) treatment can regulate the expression of dopamine transporter(DAT) in Parkinson's disease(PD) mice substantia nigra compacta(SNC).Methods: Twenty-four male mice(C_(57)BL/6J) were averagely and randomly divided into controlled group,controlled+EA group,model group and EA group.PD model mice were induced by i.p.1-methyl,4-phenyl-1,2,3,6 tetrahydropyridine.We take EA treatment with frequency from 2 to 100HZ,volt arrange from 2 to 4V,points on Hegu(LI4) and Taichong(LV3).The treatment was once daily.After 21 times treatments,we killed all mice and detected the expression of DAT by immunohistochemistry.Results:Compared to model group(2.33±3.22),the DAT positive cells are more in EA group(24.67±13.01) with significant statistical differences(P0.01).Conclusion:EA can increase the expression of DAT in PD mice SNC.
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