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《Journal of Chengdu University of Traditional Chinese Medicine》 2008-01
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Neuroprotective effects of TSG on Degeneration of Nigral Dopaminergic Neurons Induced by Paraquat and Maneb in Mice

ZHANG Ying,CHEN Jianzong,HOU Rong-rong,et al(Institute of Traditional Chinese Medicine,Laboratory of Integrated Traditional Chinese Medicine andWestern Medicine on Elderly Encephalopathy,Xijing Hospital,Fourth Military Medical University,Xi'an,Shaanxi,710032)  
Objective:To observe the role of TSG(2,3,5,4-tetrahydroxystilbene-2-O-β-D-glucoside) in preventing against PQ(paraquat) and MB(maneb)-induced apoptosis of nigral dopaminergic neurons in mouse model and the related mechanisms.Method: C57BL/6 mice were intraperitoneal injected PQ and MB to erect animal model of Parkinson's disease.Mice in 3 TSG protective groups(high,middle,low concentration group) were adiministrated with different doses of TSG(40mg/kg,80mg/kg,160mg/kg),respectively.6 weeks later,Nissl staining,tyrosine hydroxylase(TH) immunostaining were used to observe the apoptosis of nigral neurons and immunohistochemical staining was carried to detect Caspase-3 activity.Results:In TSG groups of high and middle concentrations,the loss of nissl positive and TH positive-neurons were decreased significantly,and Caspase-3 activity was also reduced obviously.Conclusion:Certain concentrations of TSG showed protective effects on apoptosis of nigral dopaminergic neurons induced by PQ and MB in mice.
【Fund】: 国家自然科学基金资助(批准号:30271646)
【CateGory Index】: R285
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 DING Zheng-Tong, REN Hui-Min, JIANG Yu-Ping Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040,China;Apoptosis of Substantia Nigra Dopaminergic Neurons in C57BL Mice Exposed to Paraquat for Different Periods[J];Chinese Journal of Clinical Neurosciences;2003-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LU Jian, HOU Shuang-ju,QIAN Mei,CHEN Cong-gui (School of Biology and Food Engineering, Hefei University of Technology, Hefei 230009,China);Research Progress on Stilbene Glucoside[J];Anhui Chemical Industry;2006-03
2 LI Yong-mei1 ,LI Xia2,3,ZHOU Zhao-li3(1.146 of Warehouse,State Food and Drug Administration,Shijiazhuang 050071,China;2.Department of Pharmacy,Ocean College of Shandong University at Weihai, Weihai 264209,Shandong Province,China;3.Department of Pharmacology,Shenyang Pharmaceutical University,Shenyang 110016,China);Proventive effects of Polygonum multiflorum Thunb.extract on nigrostriatal dopaminergic system lesion induced by paraquat in mice[J];The Chinese Journal of Clinical Pharmacology;2007-05
3 SUN Xin1,GU Yi2,LI Xiao-Feng1,LI Xiao-Bing1,CHEN Jian-Zong1 1Laboratory of Integrated Traditional Chinese Medicine and Western Medicine in Elderly Encephalopathy,Research Center of Traditional Chinese Midicine,Xijing Hospital,2Pharmaceutical Preparation Section of Stomatology Hospital,Fourth Military Medical University,Xi'an 710033,China;Effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside against MPP~+ induced apoptosis in PC12 cells[J];Journal of the Fourth Military Medical University;2009-24
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