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《Journal of Chengdu University of Traditional Chinese Medicine》 2008-03
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Essential Oil of Ligusticum Chuanxiong Hort's Influence on Expressions of COX-2 in Hypothalamus of Fever Rat

YANG Jin-rong,SONG Jun,HU Rong,et al(1.Chengdu University of Traditonal Chinese Medcine,Chengdu,610072;2.Sichuan Academy of Chinese Medicine Sciences,610051)  
Objective: to investigate the antipyretic mechanism of Essential oil of Ligusticum chuanxiong Hort(CH).Methods:The expressions of COX-2 protein in hypothalamus of brewer's yeast-induced fever rats were checked using Immunohistochemistry.ResuLts: The expressions of COX-2 protein in hypothalamus of model team are higher than normal team,expressions of teams of high and middle dose of CH are lower than model team,expression of team of low dose of CH has no obvious different with model team.Conclusion: one of the antipyretic mechanism of essential oil of Ligusticum chuanxiong Hort.(CH) may be to inhibit the expression of COX-2 protein in hypothalamus of rats,thereby reduce the content of PGE2 that lower the set point and produce antipyretic effect.
【Fund】: 四川省科技厅科研基金(05JY029-045);; 四川省教育厅科研基金(2003A044)资助
【CateGory Index】: R285.5
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