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《Journal of Chengdu University of Traditional Chinese Medicine》 2009-01
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Effect of Radix Astragali and Safflor Injection on NT-3 after Local Cerebral Ischemia/ Reperfusion in Rats

DUAN Xiao-hui1,PAN Xiao-ming2,GUO Ling-ling1,et al(1.Shenzhen People's Hospital,Second Clinical Medical College,Jinan University 2.Shenzhen Institute of Natural source drugs)  
Objective:To study the therapeutic effects of radix astragali(RA) and safflor injection on brain-derived neurotrophic factor(BDNF),in rats brains following local cerebral ischemia/reperfusion.Methods:One hundred eighty male adult SD rats were rando mLy divided into five groups: the sham-operated group,the model group,the RA group,the safflor group and the RA+safflor group.The model of middle cerebral artery occlusion(MCAO) was established by thread ligation method,and at 12h,30min before operation,rats were injected intraperitoneally corresponding medicine in different groups and the medicine was injected after operation every other 12 h.In sham-operated.group and the model group,equally dose saline was injected intraperitoneally.Neurological system symptoms were evaluated after 6h,12h,24h,48h of ischemia/ reperfusion.Then the rats were decapitated at 6h,12h,24h,and 48h after reperfusion,and rats brains were taken for immunohistochemistry and histopathological examinations.Positive immune reacted cells of BDNF are counted under light microscope at different time points of ischemia/reperfusion.Results:RA and safflor injection can significantly alleviate neurological system damage symptoms(P0.05);Histopathological examination showd that the cerebral ischemic damage in the RA and safflor group was significantly milder than that in the model group.And positive immune reacted cells amounts of BDNF were greatly enhanced in the RA+safflor group as compared with the model group,the RA group and the safflor group(P0.05).Conclusions:The protective effects of the RA and safflor injection therapy against cerebral ischemia/reperfusion injury might be associated with improving the positive expressions of BDNF.Moreover,The therapeutic effects of RA and safflor injection is superior than the ones of safflor or RA.
【Fund】: 广东省深圳市科技计划项目(No.200803092)
【CateGory Index】: R285.5
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