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《Journal of Chengdu University of Traditional Chinese Medicine》 2013-03
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Study on Experimental Animal Model of LDSD Syndrome Duplicated by Multi-Factor Method

ZHAO Bo;CHAI Li;WU Da-mei;Guiyang College of Traditional Chinese Medicine;  
Objective: The present study was designed to duplicate animal model of depression with LDSD( Liver-depression and spleen-deficiency) utilizing approach of multi-factor stimulus,and we have researched the approach of animal model of LDSD and its pathophysiological mechanism. Methods: Before and after duplicated,it was determined that behaviors and the levels of plasma CRH,ACTH,CORT,AVP. Results: Compared to groups of the control,Xiao-yao-san,Ketoconazole,and Dexamethasone,the CRH of model group was increased significantly( P 0. 05,P 0. 01,respectively); compared to groups of the control,Xiao-yaosan,Ketoconazole,and Dexamethasone,the CORT of model group was increased significantly( P 0. 01,respectively); meanwhile compared to groups of the control,Xiaoyaosan,Ketoconazole,and Dexamethasone,the ACTH of model group was increased significantly( P 0. 05,P 0. 01,respectively); but compared to groups of the control,Xiao-yao-san,Ketoconazole,and Dexamethasone,the AVP of model group was decreased significantly( P 0. 01,respectively). Conclusion: The experiment suggests that it is possible and successful for animal model of LDSD in CUMS and its pathophysiological changes is related to the irregulars of HPA. Adjustment of function of HPA can be pharmacodynamic mechanism of Xiao-yao-san,in which cured LDSD through.
【Fund】: 贵州省科学技术基金项目(编号:黔科合J字(2011)2302)
【CateGory Index】: R-332
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