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《Journal of Chengdu University of Traditional Chinese Medicine》 2015-04
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Effect of Compatibility of Rheum officinale Bailland Scutellaria baicalensis Georgion Pharmacokinetics of Rhein and Baicalin in Endotoxemia Rats

ZHANG Yan;LI Hong;LI Fan-fan;Department of Pharmacology,Chengdu University of Traditional Chinese Medicine;  
Objective: To investigate the effect of compatibility of Rheum officinale Baill and Scutellaria baicalensis Georgi on pharmacokinetics of rhein and baicalin in endotoxemiarats. Methods: The model rats wereinjected intravenously with lipopolysaccharide( LPS,5mg / kg). Three groups of rats were orally administeredrespectively with three decoctions including decoction of Rheum officinale Baill( 1. 54 g / kg),decoction of Scutellaria baicalensis Georgi( 0. 77 g / kg) and blenddecoction ofRheum officinale Baill and Scutellaria baicalensis Georgi( 2. 31 g / kg). The bloods were sampled at different time points to determine the drug concentration of rhein and baicalin in serum by HPLC-FLD and HPLC-MS separately. Main pharmacokinetic parameters were calculated by Kinetica 5. 0software. Results: The pharmacokinetic parameters showed that Cmaxand AUC of rhein and baicalin were both obviously increased,T1 /2and MRT were both obviously prolonged when Rheum officinale Baill was combined with Scutellaria baicalensis Georgi. Conclusion:The elimination process of rhein and baicalin were remarkably prolongedand the bioavailability significantlyenhanced after compatibility. The effect of decoction which decocted together was more prominent than which used separately.
【Fund】: 国家自然科学基金项目(编号:81274111)
【CateGory Index】: R285.5
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