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《Journal of Changchun University of Science and Technology(Natural Science Edition)》 2008-02
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Study on Anti-tumor Activity from Fungi Polysaccharide

ZHANG Qin1,YU Hang2,CHEN Xiaoying2,MA Dezhang 2,XU Ren2,YU Yuanhua2(1.Changchun Institute of Education,Changchun,130022;2.School of LifeScience,Changchun University of Science and Technology,Changchun,130022)  
In this paper,Mongolia Tricholoma polysaccharide(MOP) and purple mushroom polysaccharides(COP) were as the experimental materials,a single polysaccharide components separately and mixed polysaccharide components(MCP) were used in vitro and in vivo anti-tumor experiments,with MTT assay determination of the MOP,COP,MCP of liver cancer cells(HepG2) and human cervical cancer cells(Hela) inhibition,and to make use of statistical methods for analysis.The results show that MCP inhibited effect is the best,and the inhibition rate of MCP about HepG2 is 72.33 percent,the Hela is 80.68 percent.MCP affected on S180 in KM mice significantly also,the greatest inhibition rate reached to 58.74 percent,and has shown a good dose-effect relationship.The results provide a research foundation for the development of dual-fungal sugar anticancer drug.
【Fund】: 吉林省科技厅资助项目(200504025)
【CateGory Index】: R730.5
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