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《Urban Environment & Urban Ecology》 2003-01
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Acute Toxicity and Estrogenic Effect of Butylbenzyl Phthalate in Enviroment

LI Wenlan1,JI Yubin2,YANG Bo2,LU Dongyang2,JIANG Anxi1(1.College of Civil Environmental Engineering,Harbin University of Technology,Harbin150090,China;2.Dept of Pharmaceutical Engineering,Harbin University of Commerce, Harbin150076,China)  
Butylbenzyl phthalate is widely used in daily lives. In order to clarify the toxicity and estrogenic effect of Butylbenzyl phthalate in environment, the LD50 of acute toxicity test is mensurated to be 10.2g/kg. Estrogenic activity is detected by in vivo uterine weight method in mice. The result indicates that Butylbenzyl phthalate of lower dose displays no estrogenic activity. When dose of Butylbenzyl phthalate is 8uL (8.96mg) the weight of mice uteri has a comparatively obvious augment, which shows estrogenic activity. The weight of mice uteri increases prominently with the dose of Butylbenzyl phthalate increasing to 16uL (17.92mg) and 32uL (35.84mg), the effect of which is approximately equal to that of dihydrotheelin of 1ug, even greater than it when it reaches to 64uL (71.68mg). The result of the test proves that Butylbenzyl phthalate of ostensibly safe dose has dominantly estrogenic activity.
【Fund】: 黑龙江省普通高等校骨干教师创新能力资助计划项目([2001]01502)
【CateGory Index】: X830
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