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《China Surfactant Detergent & Cosmetics》 1992-06
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Preparation, Nature of the Modified Superoxide Dismutase and its Ap-plication in Cosmetic Industry

Abstract: Superoxide dismutase is modified with fatty acid and hyaluronic acid to improve its stability.the resulting conjugate of SOD with fatty acid and hyaluronic acid have a 15h half-life in rats,vs.5min for unmodified SOD. The modified SOD thus prepared retains 90-93% of unmodified SOD activity. The fatty acid-SOD and hyaluronic acid-SOD show greater resistance to pepsin degradation,enhanced heat and pH changes. The fatty acid-SOD is 4500u/mg protein MW 38000d, hyaluronic acid-SOD is 1013u/mg Protein MW 83000d. The preparations may be used as a enzymes for pharmaceutical, cosmetics and food additives.
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