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《China Surfactant Detergent & Cosmetics》 2009-01
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Preparation of insulin nanocapsules by interfacial polymerization in microemulsion

ZHU Yin-yan,AN Xue-qin(Jiangsu Key Laboratory of Biofunctional Materials,College of Chemistry and Environmental Science,Nanjing Normal University,Nanjing 210097,China)  
Insulin nanocapsules were prepared by means of interfacial polymerization of poly(ethyl 2-cyanoacrylate)in microemulsions formed by block copolymer surfactant as emulsifier.Particle size of the nanocapsules achieves a small value around 100 nm that is corresponding to the size of the droplet in the microemulsion,which acts as the templet.Composition of the microemulsion has a big influence on the particle size of the nanocapsules.By means of this method,the extent of encapsulation of the product achieves than 90% or more.The releasing behavior of insulin from the nanocapsules of the product was examined.
【Fund】: 国家自然科学基金资助项目(20673059);; 江苏省普通高校自然科学研究计划资助项目(07KJD150099)
【CateGory Index】: TB383.1
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