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《中国肿瘤临床(英文版)》 2008-03
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Correlation between Expression of P38 MAPK-Signaling and uPA in Breast Cancer

Yanchun Han1 Luying Liu1 Dongxia Yan1 Guihua Wang2 1Department of Pathology;2Department of Physiology,Binzhou Medical University,Bin-zhou 256603,Shandong Province,China.  
OBJECTIVE To study the expression of phosphorylated p38 mitogen-activated protein kinase(p-p38)and uPA and the correlation of their expression with breast cancer clinicopathological characteristics,and to investigate the role of the p38MAPK-signaling pathway in regulating uPA expression in breast cancer cells. METHODS Immunohistochemistry(S-P) was used to test the expression of p-p38 and uPA in 60 specimens of breast cancer tissues.Western blots were adopted to detect expression of the p-p38 and uPA proteins in MDA-MB-231 and MCF-7 breast cancer cells,and uPA expression a er treatment with SB203580,a specific inhibitor of p38 MAPK. RESULTS The positive rate of the p-p38 protein and uPA protein expression in the breast cancer tissues was 56.7% and 60.0%,respectively.The expression of p-p38 was positively related to the expression of uPA(r=0.316,P0.05).The expression of p-p38 and uPA was related to lymph node metastas is and the TNM stage(P0.05),but it was not related to the patient’s age or tumor size(P0.05).The expression of p-p38 and uPA in MDA-MB-231 cells was higher than that in MCF-7 cells.SB203580 inhibited the p38 MAPK pathway and reduced uPA protein expression. CONCLUSION The p38 MAPK-signaling pathway promotes breast cancer malignant progression by up-regulating uPA expression,and it may be an important process in breast cancer invasion and metastasis.
【CateGory Index】: R737.9
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【References】
Chinese Journal Full-text Database 1 Hits
1 Wang Xiao-hui1, Tang Xu-lei21Department of Endocrine, Gansu Hospital of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China; 2Department of Endocrine, the First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China;Effects of p38MAPK on the proliferation, differentiation and apoptosis of murine osteoblasts[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-37
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Tyler ZARUBIN, Jiahuai HAN* Department of Immunology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA;Activation and signaling of the p38 MAP kinase pathway[J];细胞研究(英文版);2005-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 JIANG Shujun YANG Lijuan DIAO Huiling WANG HuaDepartment of Physiology,Binzhou Medical University,Binzhou 256603;Expression of p38 MAPK in cerebral ischemia core and penumbra in rats with focal cerebral ischemia[J];Journal of Binzhou Medical University;2009-05
2 LI Jing, XU Feng, HU Lan, TAN Li-ping, FU Yue-qiang, FANG Fang, KUANG Feng-wu, LU Zhong-yi (Intensive Care Unit, Children’s Hospital, Chongqing Medical University, Chongqing 400014, China);Effect of hyperoxia on p38MAPK expression and apoptosis in the lungs of juvenile rats[J];Acta Academiae Medicinae Militaris Tertiae;2008-17
3 LUO Li-Man1, SUN Zhi-Qiang2, YU Jian1, NIE Guo-Ming1, LIU Jing1, ZOU Min-Shu11Department of Paediatrics, 2Department of Radiology, Wuhan General Hospital, Guangzhou Military Command, Wuhan 430070, China;Effect and mechanism of protection from hyperoxia-induced lung injury in new-born rats by SB203580[J];Journal of the Fourth Military Medical University;2007-19
4 Hai-Feng Zhang,Yan-Yan Zhong,Xiao-He Lu Department of Ophthalmology,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,Guangdong Province,China;Advances on p38 signal transduction pathway and corneal neovascularization[J];International Journal of Ophthalmology;2011-09
5 LUO Liman1,SUN Zhiqiang2,YU Jian1,NIE Guoming1,XU Hongtao1,ZOU Minshu1,TIAN Hao1,YANG Xinfeng11Dept.of Paediatrics,2Dept.of Radiology,Wuhan General Hospital,Guangzhou Military Area Command,P.L.A,Wuhan 430070,China;Protection of P38MAPK Inhibitor SB203580 from Hyperoxia-Induced Lung Injury in New-Born Rats[J];Medical Journal of Wuhan University;2008-04
6 YU Zhe,XING Fei-yue,WANG Tong,ZHOU Jian-guo,ZENG Yao-ying (Institute of Tissue Transplantation and Immunology,Jinan University,Guangzhou 510632,China);Effect of p38 mitogen-activated protein kinase on the proliferation of mouse T lymphocytes[J];Journal of Jinan University;2006-04
7 He Yun,Zhang Weili,Bi Yang,Li Shijun,Zhang Bo The Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China;Expression of p38 MAPK in rat model with chronic nonbacterial prostatitis[J];Chinese Journal of Andrology;2008-12
8 LU Mao,YE Jun-ru,FAN Yuan-chun,et al.The First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan 610500,China;Expression of phosphorylate-p38 mitogen-activated protein kinase in skin squamous cell carcinoma and its significance[J];Sichuan Medical Journal;2009-12
9 HUANG Yu-ge1,FENG Zhi-chun2,YU Yan-liang1,XIAO Fang-fang1(1.Department of Pediatrics,Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001,China;2.Bayi Children's Hospital,The Military General Hospital of Beijing PLA,Beijing 100700,China);Protective effects of MG-132 on p38 signaling pathway and cell apoptosis in lung injury induced by hyperoxia[J];Journal of Shanghai Jiaotong University(Medical Science);2009-08
10 Yi Zeng1, 2, Zhong Yang3, Yangyun Han2, Chao You1 1Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China 2Department of Neurosurgery, People’s Hospital of Deyang City, Deyang 618000, Sichuan Province, China 3Department of Neurobiology, the Third Military Medical University, Chongqing 400038, China;Screening of differentially expressed genes related to differentiation and proliferation by gene expression profiling of different grade astrocytoma cell lines[J];中国神经再生研究(英文版);2008-03
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 LI Rongshan 1, 2 , DING Tao 2 , LIU Xiaocheng 1 , LI Caixia 2 1 Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2 Department of Nephrology, Second Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China;Influence of SB203580 on Cell Apoptosis and P38MAPK in Renal Ischemia/Reperfusion Injury[J];Journal of Huazhong University of Science and Technology(Medical Sciences);2006-01
2 LU Meisong 1, XIAO Lan 2, LI Zhimin 3, HU Jianli 4 1Department of Gynecology and Obstetrics, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China 2 Department of Gynecology and Obstetrics, the Third Affiliated Hospital of Sun Yan-sen University, Guangzhou 510630, China 3Department of Gynecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 4The Cancer Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, China;The Relationship between p38MAPK and Apoptosis during Paclitaxel Resistance of Ovarian Cancer Cells[J];华中科技大学学报(医学英德文版);2007-06
3 Meisong LU , Lan XIAO , Jianli HU , Suo DENG , Yan XU 1Department of Obstetrics and Gynecology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China 2Department of Obstetrics and Gynecology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China 3Center of Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Targeting of p38 Mitogen-activated Protein Kinases to Early Growth Response gene1 (EGR-1) in the Human Paclitaxel-resistance Ovarian Carcinoma Cells[J];华中科技大学学报(医学英德文版);2008-04
4 LIAO Qingchuan, XIAO Zhousheng, QIN Yanfang, et al. Institute of Clinical Pharmacology, Central South University, Changsha 410078, China;p44/42 and p38 MAPKs exert differences functions in osteoblastic differentiation of mouse bone marrow-derived mesenchymal stem cell cultures[J];Chinese Journal of Osteoporosis;2004-03
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 BAI Xue-dong1,HU Yun-yu2,LI Hang2,HOU Li-sheng1,LI Hai-feng1 1Department of Orthopaedics,the Naval General Hospital,Beijing 100037;2Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China;The construction of recombinant adenovirus containing p38MAPK gene and its expression in mouse osteoblast-like cells(MC3T3-E1)[J];Chinese Journal of Cellular and Molecular Immunology;2011-04
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