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《Chinese Journal of Neuro-Oncology》 2004-03
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Chemotherapy for Brain Metastases

Wen Zhang Da-tong Chu Department of Medical Oncology,Cancer Hospital & Institude,CAMS & PUMC,Beijing 100021,P.R.China  
Brain metastases are the most common intracranial tumor of adults,and the incidence of brain metastases is increasing.Because the majority of cytotoxic agents seem to be unable to penetrate the blood-brain barrier,the role of chemotherapy in the treatment of brain metastases remains controversial.In the fact,the blood-brain barrier is disrupted in brain metastases,and does not limit the response to chemotherapy. The most important factor affecting the response to cytotoxic agents is the chemosensitivity of different tumors.New- er drugs are now on study:temozolomide seem to be particularly promising(alone or in association with other drugs)in the treatment of various brain metastases.
【CateGory Index】: R739.4
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