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Thermosensitive Poly(N-isopropylacrylamide) and Its Application

REN Yanrong~1 HUO Danqun~1 HOU Changjun~2 (1 Chongqing University Bioengineering College, Key Lab for Biomechanics & Tissue Engineering under the State Education Ministry, Chongqing 400044; 2 College of Chemistry and Engineering,Chongqing University, Chongqing 400044)  
As Poly (N-isopropylacrylamide) not only has hydrophilic acylamino, but also has hydrophobic isopropyl, it shows favorable thermo sensitivity. It is widely used as a new kind of intelligent material and its intelligence and memory effect become the hot spots in international macromolecule field. The paper reviews the thermosensitive mechanism, the classification and characteristic of synthesis of poly (N-isopropylacrylamide), its applications in drug delivery, enzyme immobilization, material separation, immunoanalysis and biological macromolecule material in medicine. The study directions for future are also pointed out.
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