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《Materials Review》 2008-12
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Preparation and Drug Release Property of Sodium Alginate/Gelatin/Chitosan Blend Hydrogel Drug-loaded Microspheres

ZHANG Kun~1 LI Jing'an~1 CHENG Liping~2 LI Yunfeng~2 ZHANG Zhibin~(1,2) (1 College of Bioengineering,Southwest Jiaotong University,Chengdu 610031;2 College of Materials, Sichuan University,Chengdu 610065)  
In this study,the compound of sodium alginate(SA),gelatin hydrochloride(GT),and tetracycline hydrochloride(TC),a model antibiotic drug,is dropped into chitosan(CS)at ambient temperature.Polymeric blend hydrogel drug-loaded microspheres of sodium alginate/gelatin/chitosan/tetracycline hydrochloride,with three kinds of SA/GT ratios,are prepared by solidifying with calcium chloride(CaCl_2),The effects of different ratios on the release property of TC are discussed under simulated gastrointestinal pH conditions(2.0,7.4).The highest TC envelopment is obtained from 10/0.8 SA/GT ratio.It is also observed from release results that TC release from the micropheres through the external medium is much higher at pH(2.0)than that at pH(7.4).Then the sodium alginate/gelatin/chitosan blend hydrogel microspheres will be a new medicinal carrier for its good controlled release and degradation property.
【Fund】: 国家自然科学基金资助项目(50573061);; 四川省应用基础研究项目(07JY029-065);; 西南交通大学科学研究基金资助项目(2006B52)
【CateGory Index】: TB383.4
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【Citations】
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1 ZHANG Ai-hua,YAO Kang-de(Institute of Polymer Materials,Tianjin University,Tianjin 300072,China);Preparation and in vitro Release of Icariin-loaded Chitosan/Gelatin Microspheres[J];Chinese Polymer Bulletin;2006-04
【Co-citations】
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1 Zhang Kun Zhao Yuqiang Yi Jian Zhang Zhibin(College of Bioengineering,Southwest Jiaotong University,Chengdu 610031);Effect of different conditions on the sodium alginate/gelatin/chitosan blend beads' swelling[J];New Chemical Materials;2008-05
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【Secondary References】
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1 LI Rui-ge,LI Ding,ZHU Chun-shan(School of Chemistry and Chemical Engineering,Henan University of Technology,Zhengzhou 450001,China);Preparation and Drug-release in Vitro of β-Cyclodextrin-co-Succinic Anhydride Magnetic Polymer Microspheres[J];Liaoning Chemical Industry;2011-06
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