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《CHONGQING MEDICAL JOURNAL》 1999-06
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The Effects of Fluctuating Extracellular High Glucose Concentration on Glomerular Mesangial Cells

Qiu Hongyu;Qu Suiliin;Liu Xiaohui;Yang Lichuan (Nephrology Division,Department of Internal Medicine, the First Affiliated Hospital, WCUMS, Chengdu, Sichuan 610041)  
Objective: In Order to observe the effects of hyperlgycemia on Mesangial cell(MsC). The effects of fluctuating extracellular high glucose(FEHG) on the proliferation and fibronectin (Fn) synthesis were studied. Methods:The Fn level in supernatant of culturedd MsC and MsC Proliferation were assessed by means of competitive inhibiting ELISA method and MTT colormetric method respectively. Results: High glucose levls inhibited the MsC proliferation and FEHG had the same inhibition effect. the Fn synthesis in FEHG was more higher than that in high glucose level. Conclusion: Fluctuating changes in extracellular glucose concentration may play an important pathological role for FN synthesis of MsC in patients with diabetes mellitus treated inadequatly.
【CateGory Index】: R587.2
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