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《Chongqing Medical Journal》 2000-05
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Study of the Injurious Effects of Cadmium and Protective Action of Zinc on Ultrastructure of Basal Cell of Prostate in Rat

Luo Ziguo, Xu Ge ,Li Weixin Laboratory of Electron Microscopy, Chongqing University of Medical Laboratory of Electron Microscopy, Chongqing University of Medical Sciences, Chongqing, 400016  
Objective:To observe the injurious effects of cadmium (Cd) and protection of zinc(Zn) on ultrastructure of basal cell of prostate in Wistar rats. Methods:The rats were intraperitoneally injected with CdC12 (2mg/kg body weight) and Cd+Zn. The specimens were observed by transmission electron microscope. Results: Mild ultrastructural alterations of basal cells of prostate were detected 4 hours after Cd treatment. The changes became prominent within 3 days, After 15 days, the base cells had recovered almost to normal. After 60 days, the growth of basal cells was more active, but the quantity of basal cell decreased. Conclusion: Cd has direct injurious effects on the ultrastructure of basal cell of prostate in rats. Zn had some protective effect on the ultrastrucural injuries by cadmium.
【CateGory Index】: R730.2
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