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《Chongqing Medical Journal》 2002-07
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The expression and the role of TGF-β receptors and signal transduction molecule Smad4 in rat fibrotic liver

LIANG Zhi qing,XU Xin bao,HE Zhen ping (Hepatobiliary Surgery Center,Southwest Hospital, the Third Military Medical University,Chongqing 400038)  
Objective To investigate the expression and the role of TGF β receptors and signal transduction molecule Smad4 in rat fibrotic liver.Methods In situ hybridization and immunohistochemistry was used.Results The expression Smad4 and the both TGF β type Ⅱand Ⅰreceptors were significantly increased in the fibrotic liver than in the control.The Smad4 mRNA and protein was mainly in nonparenchymal cells that distributed in the portal tract,fibrous septa, and the border between liver nodule and fibrous tissue.Also the TGF β type Ⅱ and Ⅰ receptor was mostly localized in the protal tract, around sinusoid and fibrous septa.In addition, only few hepatocytes expressed the type Ⅱ receptor.Conclusion The expression of the TGF β type Ⅱ and Ⅰ receptor and signal molecule Smad4 increase with the progress of liver fibrosis.It might be an improtant factor of fibrogenesis in fibrotic liver.
【Fund】: 国家自然科学基金资助项目 (39870 832 )
【CateGory Index】: R575.2
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