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《Chongqing Medical Journal》 2003-06
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The study of glucocorticoid efficiency difference between BALB/c and C57BL/6 mice

SHEN Hai ying, ZHOU Yuan guo, LU Jing li, et al. (Research Institute of Field Surgery,Daping Hospital, the Third Military Medical University, Chongqing 400042, China)  
Objective To observe the glucocorticoid efficiency difference between BALB/c and C57BL/6 mice and also to study its molecular mechanism. Methods RIA, Western blot and EMSA methods were used to detect serum concentration of cortisol, expression of glucocorticoid receptor (GR) and glucocorticoid response element (GRE) binding efficiency in brain tissue. Results The different efficiency of Gc GR pathway was confirmed between BALB/c and C57BL/6 mice. GRE binding efficiency and the ratio of nucleus/cytoplasm of GR in the brain tissue of C57BL/6 mice were significantly higher than those of BALB/c mice, while there was no significant difference of the concentration of cortisol and cytoplasmic GR in the brain tissue of the two strains of mice. Conclusion The difference of GR nucleic translocation may play an important role in the different efficiency of Gc GR pathway between BALB/c and C57BL/6 mice via regulating GRE binding.
【Fund】: 国家自然科学基金资助项目 (30 1 0 0 1 0 6) ;; 全国优秀博士论文基金资助项目 (2 0 0 1 56)
【CateGory Index】: R602
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