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《Chongqing Medical Journal》 2003-06
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Effect of arsenic trioxide on angiogenesis of a heterologous graft model for human breast infiltrating duct carcinoma in nude mice

CHEN Xin, WU Chen yi. (Department of General Surgery,the First Affiliated Hospital,Chongqing University of Medical Sciences, Chongqing 400016, China)  
Objective To investigate the antitumor angiogenesis activity of arsenic trioxide on a heterologous graft model for human breast infiltrating duct carcinoma in nude mice. Methods Completely random design, mice bearing tumor were divided into four groups, which were injected by a tail vein in sodium chloride, arsenic trioxide and cisplatin for 7 days. The intratumoral microvessel density(MVD) and expression of vascular endothelial growth factor(VEGF) were evaluated by immunohistochemical staining in breast tumor.Results The tumors in arsenic trioxide and cisplatin groups showed significantly lower MVD and VEGF expression than those in sodium chloride group( P 0.05). The tumors in arsenic trioxide groups showed significantly lower MVD expression than those in cisplatin group( P 0.05).But the tumors between arsenic trioxide 1.5 mg·kg -1 ·d -1 and 3.0 mg·kg -1 ·d -1 groups didn't show significantly MVD different expression( P 0.05).And then those in arsenic trioxide and cisplatin groups also didn't show significantly VEGF different expression( P 0.05). There was clear linear correlation between MVD and VEGF expression( r =0.9537, P 0.05).Conclusion Arsenic trioxide has obvious antitumor angiogenesis activity on a heterologous graft model for human breast infiltrating duct carcinoma in nude mice.
【Fund】: 重庆市卫生局医学科研项目资助 (0 1 2 0 4 7)
【CateGory Index】: R737.9
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