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《Chongqing Medical Journal》 2003-07
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Expression of MMp_2、MMP_9 and PCNA in colorectal tumors and its clinical implication

LI Xiao chuan,WANG Yan qing (1.Department of General Surgery,Municipal Hospital of Qingdao,Shandong Provice,Qingdao 266011,China;2.Dpeartment of General Surgery,the First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China)  
Objective To investigate the expression of MMP 2? MMP 9 and PCNA in colorectal tumors, and to discuss their effect on the progress of colorectal carcinoma. Methods The immunohistochemical staining with S P method was used to detect the expression of MMP 2?MMP 9 and PCNA in paraffin sections from 52 patients with colorectal carcinoma?15 patients with colorectal adenoma and 10 normal colorectal mucosal tissues .Results (1) The expression intensity and rate of MMP 2? MMP 9 and PCNA(strong expression rate) increased in turn by normal mucosal tissues? colorectal adenomas and colorectal carcinoma, and there were marked differences among them. (2) The expression was markedy correlated between MMP 2 and MMP 9, MMP 2 and PCNA, MMP 9 and PCNA in colorectal carcinoma. (3) The expression of PCNA in colorectal carcinoma was closely associated with differentiation and lymph node metastasis. The poorer the differentiation was, the stronger the PCNA expression was, and it was easier to make metastasis.Conclusion Overexpression of MMP 2?MMP 9 faciliates the malignant progress of colorectal carcinoma; The expression of PCNA is related to differentiation?lymph node metastasis and clinical stage of colorectal carcinoma, it is a reliable marker for proliferative activity and malignant level of colorectal carcinoma; The proliferative activity of colorectal cancer cells correlate with their secretion of MMP 2?MMP 9.
【CateGory Index】: R735.3
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