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《Chongqing Medical Journal》 2005-01
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Clinical study on applying urinary albumin/creatinine values test to diagnose and treat early diabetic nephropathy in type 2 diabetes

DENG Xiao-chu (Department of Endocrinology, Chongqing Eighth People's Hospital, Chongqing 400015,China)  
Objective To investigate the feasibility of applying urinary albumin to creatinine ratio (ACR) test on the first-morning urine sample to diagnose early diabetic nephropathy (DN) in outpatient with type 2 diabetes mellitus (T 2DM), and to analyse the effect of intervention for these subjects. Methods ACR was performed to screen microalbuminuria (MA).One hundred and fourty-eight subjects who were measured by at least two separate urine specimens in 3-month were divided into two groups: microalbuminuria group (MA group) and normoalbuminuria group (NA group). Intervention was given by following these patients with MA. The clinical characteristics of two groups were compared and the intervenient effect was studied in MA group.Results The prevalence of MA was 48.7% that revealed a significant positive correlation with duration of diabetes and/or hypertension. After 6 to 30 months (13.4±6.9 ), significant reductions of albumin levels from baseline were observed in MA group.Conclusion It is simple as well as feasible that MA is screened and monitored by using ACR in outpatient, which there are a potential beneficial effect in the prevention or treatment of renal and vascular complications of T 2DM.
【CateGory Index】: R587.2
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