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《Chongqing Medical Journal》 2005-04
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The effect of quercetin on proliferation and apoptosis of A549 lung cancer cell

LUO Jin-yong , LI Lin, YIN Yi-bing (Department of Diagnosis Laboratory,Chongqing University of Medical Science,Chongqing 400016,China)  
Objective To study quercetin′s effect on proliferation and apoptosis of A549 lung cancer cell.Methods The inhibition of quercetin on A549 cell was evaluated by means of MTT, cell cycle and apoptosis were observed by flow cytometry and electron microscopy, the expression of P53 and Bcl-2 were analyzed by immunocytochemistry.Results Quercetin inhibited cell growth in concentration and time dependent manners, prevented A549 cell entering G2/M+S from G0/G1 phase, and induced apoptosis. In the result of immunocytochemistry quercetin induced up-regulation expression of P53 and down-regulation expression of Bcl-2.Conclusion Quercetin can inhibit growth and induce apoptosis of lung cancer A549 cell, cell cycle is controlled in G0/G1. Meanwhile, quercetin can induce up-regulation expression of p53 and down-regulation expression of Bcl-2,which may be the mechanism of apoptosis of lung cancer cells by quercetin.
【CateGory Index】: R734.2
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