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《Chongqing Medical Journal》 2005-05
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Vacuum-assisted closure alleviate secondary tissue necrosis of pig′s infected soft tissue blast injury

LI Jin-qing,CHEN Shao-zong,LI Xue-yong,et al. (Department of Plastics and Burns,Tangdu Hospital,FMMU,Xi′an 710038,China)  
Objectives To observe whether the vacuum-assisted closure(VAC) technique could alleviate the secondary tissue necrosis of pig′s infected soft tissue blast injury.Methods Sixteen blast wounds,established by explosion of a specific type of electric detonators which were fixed at 1 cm over the skin of the shoulders and hips of 4 small white domestic pigs,were divided into two groups:Group A treated with gauze changing,and Group B treated with VAC set the pressure at-15 kPa.All wounds were left untreated until the third day after explosion and subsequently were infected.The data of wound area and wound depth,along with the specimens of wound bed,were collected at different time points.The specimens were processed for immunohistochemistry to detect the Ki67 and the Factor Ⅷ related antigen positive cells.Results Compared with those of Group A,all wounds of Group B enjoyed minor secondary necrosis and earlier granulation tissue formation (P0.01).Conclusions VAC could alleviate the secondary tissue necrosis of pig′s infected soft tissue blast injury and could accelerate the wound healing.
【CateGory Index】: R641
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