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《Chongqing Medical Journal》 2005-06
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Hyperglycemia lowing effect of total saponins from three-soybean liquid

LIU Yi,XIONG Xiao-yun,TANG Guo-hui (1.Department of public health, Xi'an Jiaotong University, Xi'an 710049,China; 2.Department of Pharmacology, Fourth Military Medical University, Xi'an 710032,China)  
Objective To investigate the hyperglycemia lowing effect of total saponines from Three-soybean liquid(TS-TSL) and provide theoretical evidence for developing perfect drugs against diabetes.Methods A hyperglycemia mice model was successfully developed by treating normal Kunming mice with Alloxan (ip,200 mg/kg).Diabetic mice were screened out by measuring the level of blood glucose afer 5 d. These mice were divided into 5 groups. Xiaoke pills(3 g/kg) were used as positive control. TS-TSL was orally administered continuously at the dose of 50,100,200 mg/kg respectively for 4 w. The body weight, the level of blood glucose, the capacity of glucose tolerance, liver coefficient and kidney coefficient were detected during the 4-week experiment.Results Compared with Alloxan model group, TS-TSL was capable to improve the cardinal symptoms of diabetic mice, such as water-intake and food-intake, but had no effect on body weight. Meanwhile, TS-TSL could significantly reduce the level of blood glucose, remarkably improve the capacity of glucose tolerance and markedly increase the liver and kidney coefficient in alloxan-inducing diabetic mice.Conclusion TS-TSL was shown to exert the significant hyperglycemia lowing effect, better than Xiaoke pills.
【CateGory Index】: R285.5
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