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《Chongqing Medical Journal》 2005-07
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The therapeuetic effect of bionics electromagnetic fields in OVX-induced osteoporosis rats and its mechanism

XIE Zhao,LI Qi-hong,XU Jian-zhong,et al. (Department of Orthopedics,Orthopedic Center of PLA,Southwest Hospital, the Third Military Medical University,Chongqing 400038,China)  
Objective To investigate the therapeuetic effect of bionics electromagnetic fields and to explore the mechanism of that in postmenopausal osteoporosis.Methods The fourty 6-month old female Wistar rats were randomly divided into four different groups: ovariectomy group(OVX),sham operation group (Sham), E group (Estrogen+ OVX)and EM group(BEMF+ OVX). All rats were subjected to bilateral ovariectomy except sham operation group. After 8 weeks operation,the E group rats were given estrogen 0.5mg/kg,1/2W. EM group rats were exposed to bionics electromagnetic fields, 1h /d. OVX and Sham group rats were given nothing. After the treatments finished,the specimens of left tibia. Results After the treatment with BEMF, BMD at the lumbar spine significantly increased by 24.3% (vs. OVX),the maximum load of EM group markedly significantly increased by 22% (vs. OVX) (P0.01). The trabecular volume and trabecular connections significantly increased (vs. OVX). The TRAP concentrations in EM group decreased(vs. OVX)(P0.05),The BGP concentrations, the ALP concentrations increased (vs. OVX)(P0.05).Conclusion The BEMF are useful in the treatment of postmenopausal osteoporosis resulting from ovariectomy. Building up the osteoblasts and controlling the osteoclasts may be one of mechanisms of therapeutic effect of BEMF on postmenopausal osteoporosis.
【CateGory Index】: R58
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【References】
Chinese Journal Full-text Database 5 Hits
1 XIE Zhao,WU Xue-hui,XU Jian-zhong,et al.(Department of Orthopaedics,Shouthwest Hospital,Third Military Medical University,Chongqing 400038,China);Impact of bionics pulsed electromagnetic fields on osteocyte apoptosis of ovariectomy osteoporosis rats[J];Chongqing Medicine;2007-07
2 XEI Zhao,WU Xue-hui,XU Jian-zhong,et al.(Department of Orthopaedics,Shouthwest Hospital,Third Military Medical University,Chongqing 400038,China);Impact of bionics pulsed electromagnetic fields on expression of TGF-β_1 in bone tissue of ovariectomy osteoporosis rats[J];Chongqing Medicine;2007-08
3 XIE Yu,YAO Zhen-wei (First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China);Experimental study of vitamin K on bone histomorphometry ovariectomy-induced osteoporosis rats[J];Chongqing Medicine;2007-18
4 GUAN Zhicheng1,YANG Xiaowei1,2,WANG Liming1,ZHANG Yaou3,LIU Yingyan2(1.Laboratory of Advanced Technology of Electrical Engineering and Energy,Graduate School at Shenzhen,Tsinghua University,Shenzhen 518055,China;2.Department of Electrical Engineering,Tsinghua University,Beijing 100084,China;3.Department of Life Science,Graduate School at Shenzhen,Tsinghua University,Shenzhen 518055,China);Bio-effects of Pulsed Electromagnetic Fields on Osteoporosis[J];High Voltage Engineering;2007-02
5 HE Cheng-qi;Rehabilitation Treatment of Osteoporosis[J];Continuing Medical Education;2006-30
【Co-references】
Chinese Journal Full-text Database 1 Hits
1 SUN Wen-min,WANG Xian-ping,ZHANG Xiu-yun, et al (Yancheng First Hospital,Jiangsu Yancheng 224001,China);Interventional treatment of pulsed electromagnetic fields (PEMFs) on postmenopausal osteoporosis disease[J];Hebei Medicine;2001-11
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 MI Yan1,HU Jin-xing2,LUO Xiao1,LI Cheng-xiang1,YAO Chen-guo1,SUN Cai-xin1(1. State Key Laboratory of Power Transmission Equipment & System Security and New Technology,Chongqing University,Chongqing 400044,China; 2. Chongqing Urban Power Supply Bureau,Chongqing Electric Power Company,Chongqing 400013,China);Research Progress and Prospect of Fracture Healing Using Pulsed Electromagnetic Fields (PEMFs)[J];High Voltage Engineering;2009-05
2 GUAN Zhi-cheng1,2,SU Hua-feng1,JIA Zhi-dong1,2(1.Department of Electrical Engineering and Applied Electronic Technology,Tsinghua University,Beijing 100084,China;2.Graduate School at Shenzhen,Tsinghua University,Shenzhen 518055,China);Analysis on Magnetic Field Distribution Generated by Axisymmetric Hollow Coils Systems[J];High Voltage Engineering;2009-11
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