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《Chongqing Medical Journal》 2005-08
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The study of earlier peiod intervention of GSH on hyperoxic lung fibrosis in neonatal rats

TANG Shi-fang,LI Hua-qiang,SHI Yuan,et al.(Department of Pediatrics,Daping Hospital,the Third Midical Universty,Chongqing 400042,China)  
Objective To study effect of GSH hyperoxic lung injury in neonatal rats and to investigate the role of transforming growth factor-β_1(TGF-β_1) in hyperoxic lung fibrosis.Methods The neonatal rats were randomly divided into 3 groups:group Ⅰ air control,group Ⅱ hyperoxia control,group Ⅲ hyperoxia + GSH.At the end of the exposure,the lung histophatholoical changes were examined in all groups in 3d,7d,14d,28d.Results At 3d,7d of the exposure,there were obvious acute inflammation and wider alveolus alternation:edema,bleeding and strong express of TGF-β_1 in group Ⅱ;at 28d of exposure,there were obvious lung fibrosis.Lung pathologic changes in group Ⅲ were similar to those in group Ⅰ and there were no significant fibrosis regeneration.Conclusion TGF-β_1 may have important role in hyperoxic-induce lung fiborsis injury.The earlier period intervention of GSH can reduce lung fibrosis regeneration and exceptional alveolus development.
【CateGory Index】: R96
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