The study of earlier peiod intervention of GSH on hyperoxic lung fibrosis in neonatal rats
TANG Shi-fang,LI Hua-qiang,SHI Yuan,et al.(Department of Pediatrics,Daping Hospital,the Third Midical Universty,Chongqing 400042,China)
Objective To study effect of GSH hyperoxic lung injury in neonatal rats and to investigate the role of transforming growth factor-β_1(TGF-β_1) in hyperoxic lung fibrosis.Methods The neonatal rats were randomly divided into 3 groups:group Ⅰ air control,group Ⅱ hyperoxia control,group Ⅲ hyperoxia + GSH.At the end of the exposure,the lung histophatholoical changes were examined in all groups in 3d,7d,14d,28d.Results At 3d,7d of the exposure,there were obvious acute inflammation and wider alveolus alternation:edema,bleeding and strong express of TGF-β_1 in group Ⅱ;at 28d of exposure,there were obvious lung fibrosis.Lung pathologic changes in group Ⅲ were similar to those in group Ⅰ and there were no significant fibrosis regeneration.Conclusion TGF-β_1 may have important role in hyperoxic-induce lung fiborsis injury.The earlier period intervention of GSH can reduce lung fibrosis regeneration and exceptional alveolus development.
【CateGory Index】： R96