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《Chongqing Medical Journal》 2005-11
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Study on changes of coagulation factors in the treatment of chronic severe hepatitis with plasma exchange by using FFP or FP

WANG Yun-ying,YE Yue-hong,Li Xing-lu,et al.(The Second Affiliate Hospital,Chongqing university of Medical Sciences,Chongqing 400010,China)  
Objective To explore the changes of coagulation factors in the treatment of chronic severe hepatitis with plasma exchange by using fresh frozen plasma(FFP),frozen plasma(FP) and FFP + FP.Methods Selecting 96 patients with chronic severe hepatitis,all the patients were randomly divided into 3 groups: 32 patients were treated with plasma exchange by using FFP,32 patients by using FP,32 patients by using FFP and FP.The factors of FFP,FP and patients of pre and post treatment were observed.Results There are significant different of unstable FV and FⅧ between the FFP and FP (P0.01),but no different of stable FⅦ.PT,APTT,FV and FⅦ changed obviously but TT and FⅧ didn′t change obviously of pre and post treatment.Conclusion FP can replace FFP to treat chronic severe hepatitis with plasma exchange.
【CateGory Index】: R575.1;
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