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《Chongqing Medicine》 2006-05
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HMGB1 effects on changes in phagocytosis of alveolar macrophages in LPS-induced acute lung injury in rats

YANG Qing-hua~1,FENG Ying-kai~1,HU Ming-dong~2(1.First Hopital of P.L.A,Lanzhou 730030;2.Respiratory Disease Institute,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China)  
Objective To explore HMGB1 effects on changes in phagocytosis of alveolar macrophages in LPS-induced acute lung injury in rats.Methods LPS-induced acute lung injury rat model was developed by LPS infusion.At different time-points after LPS challenge in the presence or absence of SB,the rat tissue sample and alveolar macrophages were collected.RT-PCR was applied to examine rat lung tissue HMGB1 mRNA expression level.AM phagocytosis was detected by using chicken RBC phagocytosis assay.Comparative analysis was conducted to show the correlation between HMGB1 mRNA expression and AM phagocytosis.Results At 6h,12h,24h time point,as compared with that of normal control,the injuried rat AM phagocytosis ratio and phagocytosis index decreased significantly.By contrast,in SB group,AM phagocytosis ratio and phagocytosis index decreased significantly at 24h time point as compared with that of normal control,while at 6h,12h time point,the decrease was no significantly difference as compared with LPS group(P0.01).The injuried rat lung tissue HMGB1 mRNA expression was upregulated after LPS exposure 6-24h,SB intervention significantly ameliorated the upregulation.The relative analysis showed a significant negative correlative relationship between AM phagocytosis changes and HMGB1 expression in rat lung tissue.Conclusion High expression of HMGB1 may be involved in AM phagocytosis changes.AM phagocytosis ability decrease may be one of mechanisms of pathogenesis and development of ALI.
【CateGory Index】: R563.8
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