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《Chongqing Medicine》 2007-02
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Study of Alzheimier's disease animal model induced by multiple factors

FANG Fang ,YAN Yong ,FENG Zhan-hui ,et al. (Department of Neurology ,First Affaliated Hospital,Chongqing University of Medical Sciences,Key Laboratory of Neurology in Chongqing ,Chongqing 400016,China)  
Objective To design a new animal model of Alzheimer's disease(AD),which can more completely mimic the distinctive changes of human AD and will be very helpful in the investigation of pathogenesis and pharmacy of AD in the future. Methods Beta-amyloid 1-40 and aluminum chloride solution were injected into the lateral cerebral ventricle of SD male rats respectively for continuous 14d and 5d,10ng TGFβ1 was injected into the anterodorsal nucleus of thalamus at the first time. Respectively, one week and three months after the operation, the brain tissues of these rats were stained, the activities of their choline acetyltransferase and beta-amyloid were detected with the method of immunohistochemistry. Results (1)The neurons of the sample rats showed derangement, karyopyknosis, and their brain tissues were positive when stained by Congo red. Furthermore, senile plaques and neu-rofibrillary tangles were found in the cortex and hippocampus 3 months after the operation. (2)The activity of choline acetyl trans-ferase decreased and the beta-amyloid increased. (3)These distinctive changes can last a long time. Conclusion The model is a successful, ideal and new animal model of AD with multiple factors.
【CateGory Index】: R-332
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Chinese Journal Full-text Database 1 Hits
1 ZHANG Jie1 LONG Yinf1 HU Xiqi1 CAO Ping1 ZHRENG Yaofan1 LI Xianhui2(1.Medicine Department,clinical,class 1 grade 2006 of Jishou University,Jishou Hunan,416000,China;2 Department of Physiology of Jishou University Medicine Department,Jishou Hunan,416000,China);Advances and evaluation on research of Animal model of Alzheimer's disease[J];Chinese Journal of Ethnomedicine and Ethnopharmacy;2009-10
Chinese Journal Full-text Database 2 Hits
1 Liu chunling,et al histology and embryology department of Mudanjiang Medical College.157011;THE STUDY OF MAKING AD MODEL BY INJECTING β_AP INTO HIPPOCAMPUS OF RATS[J];Journal of Mudanjiang Medical College;2001-03
2 YANG Su-fen 1,2 , YANG Zheng-qin 1, ZHOU Qi-xin 1, WU qin 2, HUANG Xie -nan 2, SHI Jing-shan 2* (1. Department of Pharmacology, Chongqing Medical University, Chongqing 400016, China; 2. Department of Pharmacology, Zunyi Medical College, Zunyi 563003, China);Effect of ecdysterone on the expression of c-fos in the brain of rats induced by microinjection β-AP_(25-35) into the hippocampus[J];Acta Pharmaceutica Sinica;2004-04
Chinese Journal Full-text Database 1 Hits
1 FANG Fang1,YAN Yong2,FENG Zhan-hui3,LIU Xiang-qin2,WEN Ming2(1.Department of Neurology,The Ninth People Hospital of Chongqing,Chongqing 400700;2.Department of Neurology,the First Affaliated Hospital of Chongqing Medical University,The Key Laboratory of Neurology in Chongqing,Chongqing 400016;3.Department of Neurology,Tianjin First Center Hospital,Tianjin 300192,China);To Establish an Animal Model for Humans Alzheimer Disease(AD) with Closer Pathogenetic Treits bu Jointly Injecting Aβ1-40 and Aluminum into the Lateral Cerebral Ventricle of Rats[J];Chinese Journal of Neuroimmunology and Neurology;2007-06
Chinese Journal Full-text Database 7 Hits
1 Zhang Xuefei Qinghai medicai college;EFFECT ON BRAIN M-RECEPTOR IN CHRONIC ALUMINUM CHLORIDE POISONED MICE[J];Journal of Qinghai Medical College;2002-01
2 Luo Xiumei, Long Dahong, Pan Xuebing, Yang Dandi, Xuan Aiguo, Li Jiamei (Department of Anatomy, Guangzhou Medical College, Guangzhou 510182);THE STUDY ON DEMENTIA MODELS INDUCED BY INTRACEREBROVENTRICULAR INFUSION OF 192-IgG-SAPORIN[J];Chinese Journal of Neuroanatomy;2006-06
3 CHU Jin, LI Lin (Dept of Pharmacology, Xuan Wu Hospital of Capital University of Medical Sciences, Beijing 100053,China);The dementia models induced by intracerebroventricular infusion of β-Amyloid peptide in mice[J];Chinese Pharmacological Bulletin;2004-07
4 DUAN Xin 1, MA Guang yu 2, ZHANG Yan mei 3(1 Department of geriatrics, Shunde Wuzhong pei Memorial Hospital, Foshan, Guangdong 528333, China; 2 Guangdong Institute of Mental Health, Guangzhou 510180, China; 3 Laboratory of Electron Microscopy, School of Medicine Shantou University, Shantou 515041, China);Exploration on Animal Model for Senile Memory Deficits Induced by Repeatedly Giving Multiple Doses of Scopolamine to Rats[J];Acta Laboratorium Animalis Scientia Sinica;2005-02
5 YANG Jun, WANG Jing, FENG Ping_an, et al. (Anhui Institute of Medical Sciences, Hefei 230061);Effect of Naokangtai Capsule on Ability of Learning and Memory in Mice[J];TRADITIONAL CHINESE DRUG RESEARCH & CLINICAL PHARMACOLOGY;2000-01
6 Tan BaoXuan,Su wen,Chen Jiewen (Department of Physiology,Guangzhou University of TCM,Guangzhou 510405);Improvement Effect of Bajishin on Spatial Learning and Memory Abiligy of Rats[J];TRADITIONAL CHINESE DRUG RESEARCH & CLINICAL PHARMACOLOGY;2000-02
7 Yang Xiaojuan,Zhang Shenglin,Chen Yun,et al Shanxi Medical University (Taiyuan 030001);A Novel Complex Animal Model of Aged Dementia[J];Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease;2006-04
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Zhou Lihua;Chen Yici;Yao Zhibin;Gu Yaoming;Kuan Guobi(Department of Anatomy, Diuision of Brain Research ,Sun Yat-sen Uniuersity of Medical Sciences, Guangzhou);MORPHOLOGIC STUDY OF THE ANIMAL MODEL OF SENILE DEMENTIA TREATED WITH FETAL SEPTAL OR COMBINED SEPTAL WITH LOCUS CERULEUS TISSUE[J];ACTA ANATOMICA SINICA;1996-02
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