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《Chongqing Medicine》 2007-02
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Study of Alzheimier's disease animal model induced by multiple factors

FANG Fang ,YAN Yong ,FENG Zhan-hui ,et al. (Department of Neurology ,First Affaliated Hospital,Chongqing University of Medical Sciences,Key Laboratory of Neurology in Chongqing ,Chongqing 400016,China)  
Objective To design a new animal model of Alzheimer's disease(AD),which can more completely mimic the distinctive changes of human AD and will be very helpful in the investigation of pathogenesis and pharmacy of AD in the future. Methods Beta-amyloid 1-40 and aluminum chloride solution were injected into the lateral cerebral ventricle of SD male rats respectively for continuous 14d and 5d,10ng TGFβ1 was injected into the anterodorsal nucleus of thalamus at the first time. Respectively, one week and three months after the operation, the brain tissues of these rats were stained, the activities of their choline acetyltransferase and beta-amyloid were detected with the method of immunohistochemistry. Results (1)The neurons of the sample rats showed derangement, karyopyknosis, and their brain tissues were positive when stained by Congo red. Furthermore, senile plaques and neu-rofibrillary tangles were found in the cortex and hippocampus 3 months after the operation. (2)The activity of choline acetyl trans-ferase decreased and the beta-amyloid increased. (3)These distinctive changes can last a long time. Conclusion The model is a successful, ideal and new animal model of AD with multiple factors.
【CateGory Index】: R-332
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